B细胞记忆形成的表观遗传调控:B细胞表观遗传重编程的平衡模型。

IF 3.6 3区 医学 Q2 IMMUNOLOGY
Journal of Immunology Research Pub Date : 2025-07-17 eCollection Date: 2025-01-01 DOI:10.1155/jimr/9328523
Carlos Valverde-Hernandez
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引用次数: 0

摘要

B细胞免疫记忆的形成发生在第一次遇到病原体之后。在生发中心(GC), B细胞经历复杂的转录和表观遗传转变,分化为记忆B细胞(MBCs)和浆细胞(PCs)。特别是,GC B细胞向MBCs的分化一直知之甚少,对导致这种细胞命运的信号和转录因子没有明确的结论。近年来在表观遗传学和免疫记忆方面的新发现阐明了表观遗传学调节因子在建立记忆B细胞(MBC)命运中的重要作用。DNA甲基化调节因子、组蛋白修饰因子、非编码rna (ncrna)和染色质重塑因子协调了MBC表型的动态重编程。B细胞程序的正、负表观遗传调控因子在每个分化阶段相互协作,允许复杂的染色质拓扑重排和转录和翻译的动态暴露。在GC决定MBC命运之后,获得的表观遗传修饰诱导了一种平衡的调控状态,在这种状态下,基因在表观遗传上被标记为保持转录不活跃,但在刺激下会被快速激活。因此,表观遗传对基因表达的调控控制着MBC的形成,并提出了一种新的表观遗传重编程模型。该模型提供了一个关于B细胞命运如何在GC中决定和记忆形成的新视角,为改进疫苗接种和治疗方法提供了见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epigenetic Regulation of B Cell Memory Formation: A Poised Model for B Cell Epigenetic Reprograming.

Epigenetic Regulation of B Cell Memory Formation: A Poised Model for B Cell Epigenetic Reprograming.

The formation of B cell immunological memory happens after the first encounter with a pathogen. At the germinal center (GC), B cells experience complex transcriptional and epigenetic transitions to differentiate into memory B cells (MBCs) and plasma cells (PCs). In particular, the differentiation of GC B cells into MBCs has been poorly understood, and no clear conclusions on the signals and transcription factors leading to this cell fate have been identified. Recent discoveries in epigenetics and immune memory have elucidated the essential role of epigenetic regulators in establishing the memory B cell (MBC) fate. DNA methylation regulators, histone modifiers, noncoding RNAs (ncRNAs), and chromatin remodelers orchestrate a dynamic reprograming of the MBC phenotype. Positive and negative epigenetic regulators of the B cell program collaborate at each differentiation stage and allow for complex chromatin topology rearrangements and dynamic exposure to transcription and translation. Following MBC fate determination at the GC, the acquired epigenetic modifications induce a poised regulatory state where genes are epigenetically marked to remain transcriptionally inactive, but primed for rapid activation upon stimuli. Thus, a poised epigenetic control over gene expression governs MBC formation and a novel model of epigenetic reprograming is proposed. This model provides a novel perspective on how the B cell fate is determined in the GC and memory is formed, offering insights for improved vaccination and therapeutical approaches.

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来源期刊
CiteScore
6.90
自引率
2.40%
发文量
423
审稿时长
15 weeks
期刊介绍: Journal of Immunology Research is a peer-reviewed, Open Access journal that provides a platform for scientists and clinicians working in different areas of immunology and therapy. The journal publishes research articles, review articles, as well as clinical studies related to classical immunology, molecular immunology, clinical immunology, cancer immunology, transplantation immunology, immune pathology, immunodeficiency, autoimmune diseases, immune disorders, and immunotherapy.
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