生长因子在少突胶质细胞分化和成熟过程中的作用及其相互作用。

IF 11.8 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Shrey Dwivedi, Sneha Ranjan, Shuvajit Das, Jyoti Kumari, Sangeeta Singh
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引用次数: 0

摘要

少突胶质细胞(OLs)促进中枢神经系统(CNS)内的髓鞘形成。神经轴突最初缺乏髓磷脂,在发育过程中形成髓鞘。OLs来源于发育过程中的少突胶质前体细胞(OPCs),这种分化能力在整个成熟过程中持续存在。少突胶质细胞的异常分化导致各种神经系统疾病和神经退行性疾病,其特征是髓鞘形成中断,而髓鞘形成对正常的神经功能至关重要。为了制定合适的治疗策略,对少突胶质细胞分化和成熟过程的深入了解是先决条件。许多独特的生长因子,如PDGF, IGF-1, FGF等,在谱系规范的不同阶段起作用。这些因子的活性反过来又受到与其他分子(如趋化因子)协同作用的影响,以控制OL前体细胞的增殖。生长因子在少突胶质发生中的作用需要随着OL发展研究的不断涌入而不断地被重新审视。了解不同的生长因子是如何影响少突胶质细胞形成的,将有助于它们在干细胞治疗方案、OPC和OL发育的体内研究中发挥作用。这些研究的最终目的是增强各种脱髓鞘病理疾病的神经再生。我们对生长因子在少突胶质细胞分化和成熟中的作用进行了综述。此外,已作出努力确定需要进一步调查的领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of growth factors and their interplay during oligodendroglial differentiation and maturation.

Oligodendrocytes (OLs) facilitate the myelination within the central nervous system (CNS). Neuronal axons are originally devoid of myelin and acquire myelination during development. OLs are derived from oligodendrocyte precursor cells (OPCs) during development, and this ability to differentiate persists throughout maturity. The abnormal differentiation of oligodendrocytes leads to various neurological disorders and neurodegenerative diseases characterized by disruptions in myelin formation, which is crucial for proper nerve function. In order to develop suitable strategies for their treatments an intimate knowledge of oligodendrocytes differentiation and maturation processes is a pre-requisite. Numerous unique growth factors like PDGF, IGF-1, FGF, etc. function at different phases of lineage specification. The activity of these factors, in turn, is influenced by synergy with other molecules, such as chemokines to control the proliferation of OL precursor cells. The role of growth factors in oligodendrogenesis needs to be revisited constantly with the regular inflow of studies on OL development. An understanding of how different growth factors influence oligodendrogenesis will facilitate their recruitment in stem cell therapy protocols, in vivo studies on OPC and OL development. The end goal of such studies is to enhance neuroregeneration in various demyelinating pathological illnesses. We provide an overview of the research carried out on the role of growth factors on differentiation and maturation of oligodendrocytes. Besides, efforts have been made to identify areas requiring further investigation.

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来源期刊
Cytokine & Growth Factor Reviews
Cytokine & Growth Factor Reviews 生物-生化与分子生物学
CiteScore
21.10
自引率
1.50%
发文量
61
审稿时长
22 days
期刊介绍: Cytokine & Growth Factor Reviews is a leading publication that focuses on the dynamic fields of growth factor and cytokine research. Our journal offers a platform for authors to disseminate thought-provoking articles such as critical reviews, state-of-the-art reviews, letters to the editor, and meeting reviews. We aim to cover important breakthroughs in these rapidly evolving areas, providing valuable insights into the multidisciplinary significance of cytokines and growth factors. Our journal spans various domains including signal transduction, cell growth and differentiation, embryonic development, immunology, tumorigenesis, and clinical medicine. By publishing cutting-edge research and analysis, we aim to influence the way researchers and experts perceive and understand growth factors and cytokines. We encourage novel expressions of ideas and innovative approaches to organizing content, fostering a stimulating environment for knowledge exchange and scientific advancement.
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