早产儿解脲支原体感染发生率及影响因素分析。

IF 1.8 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
British journal of hospital medicine Pub Date : 2025-07-25 Epub Date: 2025-07-04 DOI:10.12968/hmed.2025.0126
Jinghua Li, Chaoqun Zhou, Fengwei Chu
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引用次数: 0

摘要

目的/背景早产新生儿感染解脲支原体(UU)的风险较高,与新生儿期许多疾病密切相关。因此,本研究回顾性分析早产新生儿UU感染的发生情况,并进一步探讨其影响因素,有助于早产儿UU感染的早期诊断。方法选取2021年6月至2024年12月在宁波大学附属阳明医院出生的早产儿870例为研究对象。93例鼻咽吸入物UU检测阳性的早产儿被纳入UU组(n = 93),而777例UU检测阴性的早产儿被纳入非UU组(n = 777)。收集两组早产儿的医疗记录和实验室检查结果。采用单因素分析和多元logistic回归分析确定影响早产儿UU感染的因素。采用受试者工作特征(ROC)曲线分析,评价不同指标对早产儿UU感染的预测效果。结果早产儿UU感染率为10.69%(93/870)。单因素分析发现,产妇年龄(p < 0.001)、妊娠期高血压(p = 0.016)、分娩方式(p < 0.001)、胎膜早破(p = 0.006)、胎龄(p = 0.001)、白细胞计数(p < 0.001)、中性粒细胞计数(p < 0.001)、血清c反应蛋白(p < 0.001)和降钙素原水平(p = 0.003)是早产新生儿UU感染的相关因素。多元logistic回归分析发现,自然分娩/产钳分娩(p < 0.001)、低胎龄(p = 0.004)和血清c反应蛋白>0.5 mg/L (p = 0.001)是早产新生儿UU感染的重要危险因素。分娩方式(自然分娩/产钳分娩)、胎龄、血清c反应蛋白(>0.5 mg/L)联合使用,曲线下面积(AUC)为0.800 (0.758 ~ 0.843,p < 0.001),敏感性为74.2%,特异性为75.3%,约登指数为0.495。结论早产儿UU感染发生率约为10%,分娩方式、胎龄、c反应蛋白水平是其独立的影响因素。这三个因素的结合在预测新生儿UU感染方面具有一定的临床潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of the Incidence and Influencing Factors of Ureaplasma urealyticum Infection in Premature Neonates.

Aims/Background Premature newborns face a higher risk of Ureaplasma urealyticum (UU) infection, which is closely associated with many diseases in the neonatal period. Therefore, this study retrospectively analysed the occurrence of UU infection in premature newborns and further explored its influencing factors, which are instrumental for enabling early diagnosis of UU infection in premature infants. Methods In this retrospective study, 870 preterm infants born in the Affiliated Yangming Hospital of Ningbo University from June 2021 to December 2024 were selected as the study subjects. Ninety-three premature infants who tested positive for UU in nasopharyngeal aspirates were included in the UU group (n = 93) as cases, whereas 777 premature infants who tested negative for UU were included in the non-UU group (n = 777). Medical records and laboratory test results of the two groups of premature infants were collected. Univariate analysis and multiple logistic regression analysis were performed to identify factors influencing UU infection in premature newborns. Predictive efficacy of indicators showing differences in predicting UU infection in premature newborns was evaluated by means of receiver operating characteristic (ROC) curve analysis. Results The incidence rate of UU infection in preterm neonates was 10.69% (93/870). Univariate analysis identified maternal age (p < 0.001), gestational hypertension (p = 0.016), delivery method (p < 0.001), premature rupture of membranes (p = 0.006), gestational age (p = 0.001), white blood cell count (p < 0.001), neutrophil count (p < 0.001), serum C-reactive protein (p < 0.001) and procalcitonin levels (p = 0.003) as factors associated with UU infection in premature newborns. The multiple logistic regression analysis identified natural birth/forceps delivery (p < 0.001), low gestational age (p = 0.004), and serum C-reactive protein >0.5 mg/L (p = 0.001) as significant risk factors for UU infection in premature newborns. Concerning the combined use of delivery method (natural birth/forceps delivery), gestational age and serum C-reactive protein (>0.5 mg/L), the area under the curve (AUC) was found to be 0.800 (0.758-0.843, p < 0.001), with a sensitivity of 74.2%, specificity of 75.3%, and Youden index of 0.495. Conclusion The incidence of UU infection in preterm infants stands at about 10%, with delivery method, gestational age and C-reactive protein level being the independent influencing factors. The combination of these three factors holds certain clinical potential in predicting neonatal UU infection.

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来源期刊
British journal of hospital medicine
British journal of hospital medicine 医学-医学:内科
CiteScore
1.50
自引率
0.00%
发文量
176
审稿时长
4-8 weeks
期刊介绍: British Journal of Hospital Medicine was established in 1966, and is still true to its origins: a monthly, peer-reviewed, multidisciplinary review journal for hospital doctors and doctors in training. The journal publishes an authoritative mix of clinical reviews, education and training updates, quality improvement projects and case reports, and book reviews from recognized leaders in the profession. The Core Training for Doctors section provides clinical information in an easily accessible format for doctors in training. British Journal of Hospital Medicine is an invaluable resource for hospital doctors at all stages of their career. The journal is indexed on Medline, CINAHL, the Sociedad Iberoamericana de Información Científica and Scopus.
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