多囊卵巢综合征对动脉粥样硬化血浆指数的影响:回顾性分析。

IF 3.3 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Huseyin Demirci, Burak Menekse, Enes Ucgul, Yuksel Onaran, Seyit Murat Bayram, Erman Cakal
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引用次数: 0

摘要

背景:多囊卵巢综合征(PCOS)是女性最常见的代谢性疾病,以慢性少月经和雄激素过多为特征,常伴有胰岛素抵抗。在多囊卵巢综合征的女性中,胰岛素抵抗、高雄激素症和脂质代谢受损会增加动脉粥样硬化的风险。方法:对我院就诊的347名多囊卵巢综合征患者和132名健康女性进行回顾性研究。采用多变量线性回归分析评估PCOS对动脉粥样硬化血浆指数(AIP)的影响。结论:PCOS患者的AIP显著高于对照组(p值)。PCOS诊断和HOMA-IR是增加动脉粥样硬化的独立危险因素。PCOS患者动脉粥样硬化负担的增加可以通过AIP来评估。在BMI为35 kg/m²或更高的患者中,观察到动脉粥样硬化性显著增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis.

Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis.

Impact of polycystic ovary syndrome on the atherogenic plasma index: A retrospective analysis.

Background: Polycystic ovary syndrome (PCOS) is the most common metabolic disorder in women and is characterized by chronic oligomenorrhea and hyperandrogenism, often accompanied by insulin resistance. In women with PCOS, insulin resistance, hyperandrogenism, and impaired lipid metabolism contribute to an increased risk of atherogenesis.

Methods: Our study was conducted retrospectively on 347 women with PCOS and 132 healthy women who presented at our clinic. The impact of PCOS on the atherogenic plasma index (AIP) was assessed using multivariable linear regression analysis.

Results: The AIP was significantly greater in women with PCOS than in controls (p-value < 0.001). A marked increase in AIP was observed when the body mass index (BMI) was ≥ 35 kg/m² (p-value < 0.001). AIP was positively correlated with BMI (r = 0.174, p-value = 0.001) and the homeostatic model assessment for insulin resistance (HOMA-IR) score (r = 0.294, p-value < 0.001). In the multivariable linear regression model including all participants, PCOS diagnosis (B = 0.146, 95% CI = 0.082-0.210; p-value < 0.001) and HOMA-IR (B = 0.017, 95% CI = 0.011-0.022; p-value < 0.001) independently predicted higher AIP. These findings identify PCOS and insulin resistance as independent risk factors for increased atherogenicity.

Conclusions: PCOS diagnosis and HOMA-IR are independent risk factors for increased atherogenicity. The increased atherogenic burden in women with PCOS can be assessed by the AIP. A significant increase in atherogenicity was observed in patients with a BMI of 35 kg/m² or higher.

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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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