{"title":"抗阻训练在不改变艾滋病毒感染者BDNF水平的情况下改善认知功能和抑郁：一项随机对照临床试验","authors":"Dayane Cristina de Souza, Kauana Borges Marchini, Pollyana Mayara Nunhes, Wagner Jorge Rodrigues Domingues, Dennis Armando Bertolini, Vitor Oliveira, Oldemar Mazzardo, Ademar Avelar","doi":"10.1007/s10461-025-04824-6","DOIUrl":null,"url":null,"abstract":"<p><p>The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).</p>","PeriodicalId":7543,"journal":{"name":"AIDS and Behavior","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.\",\"authors\":\"Dayane Cristina de Souza, Kauana Borges Marchini, Pollyana Mayara Nunhes, Wagner Jorge Rodrigues Domingues, Dennis Armando Bertolini, Vitor Oliveira, Oldemar Mazzardo, Ademar Avelar\",\"doi\":\"10.1007/s10461-025-04824-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).</p>\",\"PeriodicalId\":7543,\"journal\":{\"name\":\"AIDS and Behavior\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AIDS and Behavior\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10461-025-04824-6\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AIDS and Behavior","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10461-025-04824-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0
摘要
抗逆转录病毒疗法（ART）提供的预期寿命增加导致人类免疫缺陷病毒（HIV）感染者出现不同的合并症，特别是与衰老和精神健康有关的合并症。其中，认知障碍和抑郁症在这一人群中有所增加。因此，非药物策略，如体育锻炼，已被研究以改善这些结果。本研究旨在探讨8周的抗阻训练（RT）对HIV感染者认知功能和抑郁状态的影响。样本包括20名受试者（12名男性和8名女性），随机分为两组：对照组（CG, n = 9）和训练组（TG, n = 11）。在抗阻训练干预前后评估认知功能（Stroop Test）、抑郁状态（Beck depression Inventory- BDI）和血浆脑源性神经营养因子（BDNF）水平。结果表明，rt能够促进认知领域的显著改善，减轻抑郁症状(ΔCG: 1.56±2.46；Δtg -3.18±1.66,p > 0.001)。BDNF无明显变化（P < 0.05）。总之，8周的rt治疗改善了HIV感染者的认知功能和抑郁状态，而不改变循环BDNF水平（NCT03879993）。
Resistance Training Improves Cognitive Function and Depression Without Changing BDNF Levels in People Living with HIV: a Randomized Controlled Clinical Trial.
The increased life expectancy provided by Antiretroviral Therapy(ART) has led to the incidence of different comorbidities in people living with the Human Immunodeficiency Virus (HIV), especially comorbidities related to aging and mental health. Among these, cognitive impairment and depression increased in this population. Therefore, non-pharmacological strategies, such as physical exercise, have been studied to improve these outcomes. This study aimed to investigate the effects of eight weeks of resistance training(RT) on cognitive function and depression status in people with HIV. The sample consisted of 20 subjects (12 men and eight women), randomized in two groups: Control Group (CG, n = 9) and Training Group (TG, n = 11). Cognitive function (Stroop Test), depression status (Beck Depression Inventory- BDI), and plasma levels of Brain-Derived Neurotrophic Factor (BDNF) were assessed before and after the resistance training intervention. The results indicated thatRT was able to promote significant improvements in the cognitive domains and reduce symptoms of depression (ΔCG: 1.56 ± 2.46; ΔTG -3.18 ± 1.66, P > 0.001). Regarding BDNF, no significant change was observed (P > 0.05). In conclusion, eight weeks ofRT improves cognitive function and depression status in people with HIV, without changing the circulating BDNF levels (NCT03879993).
期刊介绍：
AIDS and Behavior provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews. provides an international venue for the scientific exchange of research and scholarly work on the contributing factors, prevention, consequences, social impact, and response to HIV/AIDS. This bimonthly journal publishes original peer-reviewed papers that address all areas of AIDS behavioral research including: individual, contextual, social, economic and geographic factors that facilitate HIV transmission; interventions aimed to reduce HIV transmission risks at all levels and in all contexts; mental health aspects of HIV/AIDS; medical and behavioral consequences of HIV infection - including health-related quality of life, coping, treatment and treatment adherence; and the impact of HIV infection on adults children, families, communities and societies. The journal publishes original research articles, brief research reports, and critical literature reviews.5 Year Impact Factor: 2.965 (2008) Section ''SOCIAL SCIENCES, BIOMEDICAL'': Rank 5 of 29 Section ''PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH'': Rank 9 of 76
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