海洋真菌青霉属（Penicillium sp. CF-06）中新的二聚吲哚二萜类化合物C和D

IF 2.2 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-07-21 DOI:10.1016/j.tet.2025.134850

Quan-Shui Wang , Wen-Bin Gao , Hong-Yan Gu , Zhi-Qin Liu , Fei Cao

{"title":"海洋真菌青霉属（Penicillium sp. CF-06）中新的二聚吲哚二萜类化合物C和D","authors":"Quan-Shui Wang , Wen-Bin Gao , Hong-Yan Gu , Zhi-Qin Liu , Fei Cao","doi":"10.1016/j.tet.2025.134850","DOIUrl":null,"url":null,"abstract":"<div><div>Two new dimeric indole-diterpenoids, dipenipenoids C and D (<strong>1</strong> and <strong>2</strong>), were obtained from the marine-derived fungus <em>Penicillium</em> sp. CF-06 by modulating fermentation conditions. Compounds <strong>1</strong> and <strong>2</strong> represent a rare and complex type of dimeric indole-diterpenoids with a C-20–C-22′ linkage. The absolute configurations of them were determined by the calculated ECD method. Compounds <strong>1</strong> and <strong>2</strong> exhibited potent effects on the differentiation of 3T3-L1 adipocytes, with lipid accumulation reduced to 92.3–16.4 % and 82.4–16.4 % at concentrations of 6.3, 12.5, 25.0, and 50.0 μM, respectively, which could provide new insights and opportunities for drug discovery in the anti-obesity arena.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"185 ","pages":"Article 134850"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dipenipenoids C and D, new dimeric indole-diterpenoids from the marine-derived fungus Penicillium sp. CF-06\",\"authors\":\"Quan-Shui Wang , Wen-Bin Gao , Hong-Yan Gu , Zhi-Qin Liu , Fei Cao\",\"doi\":\"10.1016/j.tet.2025.134850\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Two new dimeric indole-diterpenoids, dipenipenoids C and D (<strong>1</strong> and <strong>2</strong>), were obtained from the marine-derived fungus <em>Penicillium</em> sp. CF-06 by modulating fermentation conditions. Compounds <strong>1</strong> and <strong>2</strong> represent a rare and complex type of dimeric indole-diterpenoids with a C-20–C-22′ linkage. The absolute configurations of them were determined by the calculated ECD method. Compounds <strong>1</strong> and <strong>2</strong> exhibited potent effects on the differentiation of 3T3-L1 adipocytes, with lipid accumulation reduced to 92.3–16.4 % and 82.4–16.4 % at concentrations of 6.3, 12.5, 25.0, and 50.0 μM, respectively, which could provide new insights and opportunities for drug discovery in the anti-obesity arena.</div></div>\",\"PeriodicalId\":437,\"journal\":{\"name\":\"Tetrahedron\",\"volume\":\"185 \",\"pages\":\"Article 134850\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040402025004065\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402025004065","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}

引用次数: 0

摘要

通过调节发酵条件，从海洋真菌Penicillium sp. CF-06中获得了两个新的二聚体吲哚二萜类化合物，二萜类化合物C和D（1和2）。化合物1和2是一种罕见的具有C-20-C-22 '键的二聚吲哚-二萜化合物。用计算ECD法确定了它们的绝对构型。化合物1和2对3T3-L1脂肪细胞的分化有明显的影响，在6.3、12.5、25.0和50.0 μM浓度下，脂质积累分别减少到92.3 - 16.4%和82.4 - 16.4%，这可能为抗肥胖领域的药物开发提供新的见解和机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dipenipenoids C and D, new dimeric indole-diterpenoids from the marine-derived fungus Penicillium sp. CF-06

查看原文本刊更多论文

Dipenipenoids C and D, new dimeric indole-diterpenoids from the marine-derived fungus Penicillium sp. CF-06

Two new dimeric indole-diterpenoids, dipenipenoids C and D (1 and 2), were obtained from the marine-derived fungus Penicillium sp. CF-06 by modulating fermentation conditions. Compounds 1 and 2 represent a rare and complex type of dimeric indole-diterpenoids with a C-20–C-22′ linkage. The absolute configurations of them were determined by the calculated ECD method. Compounds 1 and 2 exhibited potent effects on the differentiation of 3T3-L1 adipocytes, with lipid accumulation reduced to 92.3–16.4 % and 82.4–16.4 % at concentrations of 6.3, 12.5, 25.0, and 50.0 μM, respectively, which could provide new insights and opportunities for drug discovery in the anti-obesity arena.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.