Fan Li , Yimeng Liu , Jun Wang , Yu Zhou , Junjie Tan , Hongxiang Chen , Hongye Yan , Xinghua Liao
{"title":"可注射聚乙二醇/壳聚糖原位水凝胶,具有良好的机械性能,用于伤口敷料","authors":"Fan Li , Yimeng Liu , Jun Wang , Yu Zhou , Junjie Tan , Hongxiang Chen , Hongye Yan , Xinghua Liao","doi":"10.1016/j.colsurfa.2025.137841","DOIUrl":null,"url":null,"abstract":"<div><div>To increase the water solubility of chitosan and enhance the mechanical strength of chitosan-based <em>in-situ</em> hydrogel, poly(ethylene glycol) monomethyl ether-grafted chitosan (PCS) was fabricated by a simple and efficient modification method with hexamethylene diisocyanate (HDI) as bridging agent, and then a series of poly(ethylene glycol)/chitosan-based <em>in situ</em> hydrogels (PCS@gel) were prepared from PCS and aldehyde-terminated poly(ethylene glycol) (DF-PEG) as cross-linking agent. The resultant PCS shows good water solubility in the absence of acid and its solid content is up to 8 wt%. By studying the effects of the mass ratio of PCS to DF-PEG and their solid content on the gel time and properties of PCS@gel, the results demonstrate that increasing the solid content of precursor solution can significantly shorten the gel time and improve its mechanical properties and adhesion strength. When the mass ratio of PCS to DF-PEG is 1:1, PCS@gel has a shorter gel time and higher mechanical strength. While the mass ratio of PCS to DF-PEG is 5:1, PCS@gel has better adhesion properties. Besides, PCS@gel also has good self-healing ability, antibacterial effect, low cytotoxicity and the ability to promote cell migration. Therefore, PCS@gel will have a promising application as a wound dressing.</div></div>","PeriodicalId":278,"journal":{"name":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","volume":"726 ","pages":"Article 137841"},"PeriodicalIF":4.9000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Injectable poly(ethylene glycol)/chitosan-based in situ hydrogel with wonderful mechanical property for wound dressing\",\"authors\":\"Fan Li , Yimeng Liu , Jun Wang , Yu Zhou , Junjie Tan , Hongxiang Chen , Hongye Yan , Xinghua Liao\",\"doi\":\"10.1016/j.colsurfa.2025.137841\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>To increase the water solubility of chitosan and enhance the mechanical strength of chitosan-based <em>in-situ</em> hydrogel, poly(ethylene glycol) monomethyl ether-grafted chitosan (PCS) was fabricated by a simple and efficient modification method with hexamethylene diisocyanate (HDI) as bridging agent, and then a series of poly(ethylene glycol)/chitosan-based <em>in situ</em> hydrogels (PCS@gel) were prepared from PCS and aldehyde-terminated poly(ethylene glycol) (DF-PEG) as cross-linking agent. The resultant PCS shows good water solubility in the absence of acid and its solid content is up to 8 wt%. By studying the effects of the mass ratio of PCS to DF-PEG and their solid content on the gel time and properties of PCS@gel, the results demonstrate that increasing the solid content of precursor solution can significantly shorten the gel time and improve its mechanical properties and adhesion strength. When the mass ratio of PCS to DF-PEG is 1:1, PCS@gel has a shorter gel time and higher mechanical strength. While the mass ratio of PCS to DF-PEG is 5:1, PCS@gel has better adhesion properties. Besides, PCS@gel also has good self-healing ability, antibacterial effect, low cytotoxicity and the ability to promote cell migration. Therefore, PCS@gel will have a promising application as a wound dressing.</div></div>\",\"PeriodicalId\":278,\"journal\":{\"name\":\"Colloids and Surfaces A: Physicochemical and Engineering Aspects\",\"volume\":\"726 \",\"pages\":\"Article 137841\"},\"PeriodicalIF\":4.9000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloids and Surfaces A: Physicochemical and Engineering Aspects\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927775725017443\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces A: Physicochemical and Engineering Aspects","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927775725017443","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Injectable poly(ethylene glycol)/chitosan-based in situ hydrogel with wonderful mechanical property for wound dressing
To increase the water solubility of chitosan and enhance the mechanical strength of chitosan-based in-situ hydrogel, poly(ethylene glycol) monomethyl ether-grafted chitosan (PCS) was fabricated by a simple and efficient modification method with hexamethylene diisocyanate (HDI) as bridging agent, and then a series of poly(ethylene glycol)/chitosan-based in situ hydrogels (PCS@gel) were prepared from PCS and aldehyde-terminated poly(ethylene glycol) (DF-PEG) as cross-linking agent. The resultant PCS shows good water solubility in the absence of acid and its solid content is up to 8 wt%. By studying the effects of the mass ratio of PCS to DF-PEG and their solid content on the gel time and properties of PCS@gel, the results demonstrate that increasing the solid content of precursor solution can significantly shorten the gel time and improve its mechanical properties and adhesion strength. When the mass ratio of PCS to DF-PEG is 1:1, PCS@gel has a shorter gel time and higher mechanical strength. While the mass ratio of PCS to DF-PEG is 5:1, PCS@gel has better adhesion properties. Besides, PCS@gel also has good self-healing ability, antibacterial effect, low cytotoxicity and the ability to promote cell migration. Therefore, PCS@gel will have a promising application as a wound dressing.
期刊介绍:
Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena.
The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.