通过靶向蛋白降解开发活疫苗。

IF 60.9 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-07-24 DOI:10.1038/s41577-025-01212-y

Qisi Zhang, Longlong Si

引用次数: 0

摘要

在这篇行业工具文章中，张其思和司龙龙描述了一种生产减毒活疫苗的方法，该方法涉及将病毒靶向宿主细胞的蛋白质降解机制，从而减弱宿主内的病毒，并增强病毒抗原呈递。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Live vaccine development through targeted protein degradation

In this Tools of the Trade article, Qisi Zhang and Longlong Si describe a method for generating live attenuated vaccines that involves targeting viruses to the host cells’ protein degradation machinery, which attenuates the virus within the host and also enhances viral antigen presentation.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.