钯通过分子内C-H活化催化1-（2-碘苯基）- 1h -吲哚的硅基化反应。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-07-25 DOI:10.1021/acs.joc.5c00863

Man Cao,Wenguang Li,Tongtong Zong,Heyun Sheng,Xu Zhang,Ming Chen,Wenchao Gao,Yongqi Yu,Ting Li

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引用次数: 0

摘要

研究了钯催化1-（2-碘苯基）- 1h -吲哚的C-H硅基化反应。该反应表现出明显的电子效应。该工艺以Pd(OAc)2为催化剂，六甲基二硅烷为三甲基硅基源。该反应具有良好的官能团耐受性，可以在相对温和的条件下直接获得多种含硅吲哚。

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Palladium-Catalyzed Silylation of 1-(2-Iodophenyl)-1H-indoles via Intramolecular C-H Activation.

An efficient palladium-catalyzed C-H silylation of 1-(2-iodophenyl)-1H-indoles has been developed. The reaction exhibits an obvious electronic effect. This protocol uses Pd(OAc)2 as a catalyst with hexamethyldisilane as the trimethylsilyl source. The reaction exhibits good functional group tolerance and provides straightforward access to diverse silicon-containing indoles under relatively mild conditions.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.