Philip Oluleke Ibinaiye, Benjamin Egbo, Tokan Silas Baduku, Folake Yetunde Taiwo, Kuleve Othniel Iyua, Anthony Epga Gabkwet, Emmanuel Owoicho Igoh, Daniel Stephen Pam, Moses Samuel Danjem, Jimoh Abdul Salaam, Charles Chibunna Ani
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This study investigated the relationship between physical activity and CSLD in a Nigerian population.</p><p><strong>Methodology: </strong>A case-control study was conducted in tertiary institutions in Zaria, Nigeria. A total of 362 participants were recruited, comprising 181 individuals with CSLD diagnosed via ultrasound and 181 age- and sex-matched healthy controls. Lifestyle, anthropometric, and biochemical data were collected, with physical activity levels classified into sedentary, mild, moderate, and strenuous categories. Statistical analyses, including chi-square tests and logistic regression, were performed to assess associations between physical activity and CSLD.</p><p><strong>Results: </strong>There was no significant difference in age (p = 0.5578) or sex distribution (p = 0.9160) between CSLD cases and controls. However, a significant association was observed between CSLD severity and physical activity levels (χ<sup>2</sup>= 172.1, p < 0.0001). Sedentary individuals had a higher risk of CSLD, while moderate physical activity was the most protective (OR: 0.001, p < 0.001). These findings suggest that an inactive lifestyle is a strong risk factor for CSLD.</p><p><strong>Conclusion: </strong>Sedentary behavior is an independent risk factor for CSLD, while regular physical activity, particularly moderate exercise, is protective. Public health initiatives promoting physical activity should be prioritized to mitigate CSLD progression and its complications. Further longitudinal research is needed to explore genetic predispositions and assess the long-term impact of lifestyle modifications on CSLD outcomes.</p>","PeriodicalId":94346,"journal":{"name":"Nigerian medical journal : journal of the Nigeria Medical Association","volume":"66 2","pages":"754-760"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280316/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exploring the Impact of Physical Activity on Cryptogenic Steatotic Liver Disease: A Nigerian Case-Control Study.\",\"authors\":\"Philip Oluleke Ibinaiye, Benjamin Egbo, Tokan Silas Baduku, Folake Yetunde Taiwo, Kuleve Othniel Iyua, Anthony Epga Gabkwet, Emmanuel Owoicho Igoh, Daniel Stephen Pam, Moses Samuel Danjem, Jimoh Abdul Salaam, Charles Chibunna Ani\",\"doi\":\"10.71480/nmj.v66i2.794\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cryptogenic steatotic liver disease (CSLD) is a novel subject where the liver has significant steatosis but without a known cause or abnormal cardiometabolic risk factors. 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引用次数: 0
摘要
背景：隐源性脂肪变性肝病（CSLD）是一种肝脏有明显脂肪变性但没有已知原因或异常心脏代谢危险因素的新课题。这是一个病因不明的日益严重的全球健康问题。尽管在快速城市化和生活方式改变的地区，儿童性猝死的发病率越来越高，但在尼日利亚对其风险因素的研究有限。本研究调查了尼日利亚人群中体育活动与CSLD之间的关系。方法：在尼日利亚扎里亚的高等院校进行了一项病例对照研究。总共招募了362名参与者，包括181名通过超声诊断为CSLD的个体和181名年龄和性别匹配的健康对照。收集了生活方式、人体测量和生化数据，并将身体活动水平分为久坐、轻度、中度和剧烈等类别。统计分析包括卡方检验和逻辑回归，以评估体育活动与CSLD之间的关联。结果：CSLD病例与对照组在年龄（p = 0.5578）、性别分布（p = 0.9160）上无显著差异。然而，CSLD严重程度与身体活动量之间存在显著相关性（χ2= 172.1, p < 0.0001）。久坐不动的个体有较高的CSLD风险，而适度的体育活动是最具保护作用的（OR: 0.001, p < 0.001）。这些发现表明，不运动的生活方式是CSLD的一个重要风险因素。结论：久坐行为是CSLD的独立危险因素，而规律的体育活动，特别是适度运动，具有保护作用。促进体育活动的公共卫生倡议应优先考虑，以减轻CSLD的进展及其并发症。需要进一步的纵向研究来探索遗传易感性并评估生活方式改变对CSLD结果的长期影响。
Exploring the Impact of Physical Activity on Cryptogenic Steatotic Liver Disease: A Nigerian Case-Control Study.
Background: Cryptogenic steatotic liver disease (CSLD) is a novel subject where the liver has significant steatosis but without a known cause or abnormal cardiometabolic risk factors. It is a growing global health concern with an unclear etiology. Despite the increasing prevalence of CSLD, particularly in regions undergoing rapid urbanization and lifestyle changes, there is limited research on its risk factors in Nigeria. This study investigated the relationship between physical activity and CSLD in a Nigerian population.
Methodology: A case-control study was conducted in tertiary institutions in Zaria, Nigeria. A total of 362 participants were recruited, comprising 181 individuals with CSLD diagnosed via ultrasound and 181 age- and sex-matched healthy controls. Lifestyle, anthropometric, and biochemical data were collected, with physical activity levels classified into sedentary, mild, moderate, and strenuous categories. Statistical analyses, including chi-square tests and logistic regression, were performed to assess associations between physical activity and CSLD.
Results: There was no significant difference in age (p = 0.5578) or sex distribution (p = 0.9160) between CSLD cases and controls. However, a significant association was observed between CSLD severity and physical activity levels (χ2= 172.1, p < 0.0001). Sedentary individuals had a higher risk of CSLD, while moderate physical activity was the most protective (OR: 0.001, p < 0.001). These findings suggest that an inactive lifestyle is a strong risk factor for CSLD.
Conclusion: Sedentary behavior is an independent risk factor for CSLD, while regular physical activity, particularly moderate exercise, is protective. Public health initiatives promoting physical activity should be prioritized to mitigate CSLD progression and its complications. Further longitudinal research is needed to explore genetic predispositions and assess the long-term impact of lifestyle modifications on CSLD outcomes.
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