Heber Isac Arbildo-Vega, Fredy Hugo Cruzado-Oliva, Franz Tito Coronel-Zubiate, Rubén Aguirre-Ipenza, Joan Manuel Meza-Málaga, Sara Antonieta Luján-Valencia, Eduardo Luján-Urviola, Adriana Echevarria-Goche, Carlos Alberto Farje-Gallardo, Tania Belú Castillo-Cornock, Katherine Serquen-Olano, Tania Padilla-Cáceres, Luz Caballero-Apaza
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Emerging research suggests a possible link between PD-induced systemic inflammation and neurodegeneration observed in AD.</p><p><strong>Objective: </strong>Employ an umbrella review to look into the association between periodontal disease and Alzheimer's disease.</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted until March 2025 across various electronic databases, including: PubMed, Cochrane Library, Scopus, SciELO, Web of Science, Google Scholar, ProQuest, and OpenGrey, and Dissertations and Theses. There were no time or language restrictions on the inclusion of systematic reviews (SR), with or without meta-analysis, as long as they looked at primary research that connected PD and AD. The following were excluded: preclinical and fundamental research, summaries, comments, case reports, protocols, personal opinions, letters, posters, literary or narrative reviews, fast reviews, intervention studies, and observational studies. 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引用次数: 0
摘要
背景：阿尔茨海默病（AD）和牙周病（PD）都是全球患病率不断上升的慢性疾病。新兴研究表明，pd诱导的全身性炎症和AD中观察到的神经变性之间可能存在联系。目的：采用综合综述的方法探讨牙周病与阿尔茨海默病之间的关系。材料和方法：到2025年3月，对各种电子数据库进行了全面的检索，包括：PubMed， Cochrane Library, Scopus, SciELO, Web of Science，谷歌Scholar， ProQuest和OpenGrey，以及论文和论文。纳入系统评价（SR）没有时间或语言限制，无论是否进行meta分析，只要他们研究的是与PD和AD相关的主要研究。以下内容被排除在外：临床前和基础研究、摘要、评论、病例报告、方案、个人意见、信件、海报、文学或叙述性评论、快速评论、干预研究和观察性研究。采用AMSTAR-2技术评估纳入研究的质量和总体置信度。结果：第一次检索后共检索到358个条目。在应用选择标准后，剩下16篇文章供进一步审查。比值比（OR）和风险比（RR）分别在1.67 ~ 2.17和1.11 ~ 2.26之间，有14项研究显示PD与AD之间存在相关性。结论：根据SR的研究结果和结论，显示出较高的总体可信度，我们确定PD和牙齿脱落与AD存在关联。系统综述注册：在开放科学框架（OSF）中注册：DOI 10.17605/OSF. io /GS367。
Association between periodontal disease and Alzheimer's disease: umbrella review.
Background: Alzheimer's disease (AD) and periodontal disease (PD) are both chronic conditions with rising global prevalence. Emerging research suggests a possible link between PD-induced systemic inflammation and neurodegeneration observed in AD.
Objective: Employ an umbrella review to look into the association between periodontal disease and Alzheimer's disease.
Materials and methods: A comprehensive search was conducted until March 2025 across various electronic databases, including: PubMed, Cochrane Library, Scopus, SciELO, Web of Science, Google Scholar, ProQuest, and OpenGrey, and Dissertations and Theses. There were no time or language restrictions on the inclusion of systematic reviews (SR), with or without meta-analysis, as long as they looked at primary research that connected PD and AD. The following were excluded: preclinical and fundamental research, summaries, comments, case reports, protocols, personal opinions, letters, posters, literary or narrative reviews, fast reviews, intervention studies, and observational studies. The quality and general confidence of the included studies were evaluated using the AMSTAR-2 technique.
Results: A total of 358 items were found following the first search. 16 articles were left for additional review after the selection criteria were applied. With odds ratios (OR) and risk ratios (RR) ranging from 1.67 to 2.17 and 1.11 to 2.26, respectively, 14 studies showed a correlation between PD and AD.
Conclusions: Drawing from the findings and conclusions of the SR demonstrating a high overall confidence, it's established that PD and tooth loss exhibit an association with AD.
Systematic review registration: Registered in the Open Science Framework (OSF): DOI 10.17605/OSF.IO/GS367.
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