青少年纤维肌痛患者分型:多感觉超敏反应和神经生理相关因素的作用。

IF 2.1 3区 心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL
Laura Martín-Herrero, Maria Suñol, Saül Pascual-Diaz, Tracy V Ting, Jonathan A Dudley, Catherine Jackson, Susmita Kashikar-Zuck, Robert C Coghill, Marina López-Solà
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引用次数: 0

摘要

目的:探讨青少年纤维肌痛(JFM)患者在日常生活中对非疼痛性多感觉刺激的主观感知是否可以区分不同的群体,并研究不同群体的脑功能差异。方法:43名女性青少年JFM患者(16.56±1.01岁)和34名健康对照者(16.21±0.89岁)完成了经验证的多感觉超敏测量和fMRI多感觉任务。我们进行了平均连锁聚类分析,包括多感官敏感性的测量,并在先验定义的感兴趣区域测试了核心疾病相关特征、影响相关测量和任务诱发脑激活的组间差异。结果:我们确定了两组参与者。第一组包括22例多感觉敏感性较高的患者,第二组包括21例多感觉敏感性较低的患者和34例健康对照。第二次聚类分析,仅包括患有JFM的青少年,证实了相同的患者划分。两组患者在情感症状和应对效能上相似,但在核心症状上存在差异。患有JFM的青少年在感觉敏感度较高的情况下,左侧初级运动皮层和左侧杏仁核的大脑活动增加。结论:我们发现两组青少年JFM在他们的非疼痛多感觉敏感性方面。更严重的多感觉超敏反应与更严重的核心疾病症状相关,但不影响情感/认知调节。它还与初级运动皮层和杏仁核在多感觉刺激下的活动增加有关。该研究强调了患者亚型的潜力,以了解贡献的心理生物学机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patient subtyping in juvenile fibromyalgia: the role of multisensory hypersensitivity and neurophysiological correlates.

Objective: The aim of this study was to investigate whether we could identify groups of adolescents with juvenile fibromyalgia (JFM) based on their subjective perception of non-painful multisensory stimuli in daily life and to study brain function differences between these groups.

Method: 43 female adolescents with JFM (16.56 ± 1.01 years) and 34 healthy controls (16.21 ± 0.89 years) completed validated measures of multisensory hypersensitivity and an fMRI multisensory task. We conducted average linkage cluster analyses, including measures of multisensory sensitivity, and tested between-group differences in core disease-related features, affect-related measures, and task-evoked brain activation in a priori defined regions of interest.

Results: We identified two clusters of participants. The first cluster included 22 patients with higher multisensory sensitivities, and the second one consisted of 21 patients and 34 healthy controls with lower multisensory sensitivities. A second cluster analysis, including only adolescents with JFM, confirmed the same patient division. The two patient subgroups were similar in affective symptoms and coping efficacy but differed in core symptoms of JFM. Adolescents with JFM who experienced higher sensory sensitivities showed increased brain activation in the left primary motor cortex and the left amygdala.

Conclusions: We found two clusters of adolescents with JFM with regard to their non-painful multisensory sensitivities. Greater multisensory hypersensitivity was associated with greater severity of core disease symptoms without compromising affective/cognitive regulation. It was also associated with increased activity of the primary motor cortex and amygdala in response to multisensory stimulation. The study highlights the potential of patient subtyping to understand contributing psychobiological mechanisms.

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来源期刊
Journal of Pediatric Psychology
Journal of Pediatric Psychology PSYCHOLOGY, DEVELOPMENTAL-
CiteScore
6.00
自引率
11.10%
发文量
89
期刊介绍: The Journal of Pediatric Psychology is the official journal of the Society of Pediatric Psychology, Division 54 of the American Psychological Association. The Journal of Pediatric Psychology publishes articles related to theory, research, and professional practice in pediatric psychology. Pediatric psychology is an integrated field of science and practice in which the principles of psychology are applied within the context of pediatric health. The field aims to promote the health and development of children, adolescents, and their families through use of evidence-based methods.
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