Deep learning-based prognosis of major adverse cardiac events in patients with acute myocardial infarction: a retrospective observational study in the Republic of Korea.

Objectives: This study developed deep neural network (DNN) models capable of accurately classifying major adverse cardiac events (MACE) in patients with acute myocardial infarction (AMI) after hospital discharge, across 3 follow-up intervals: 1, 6, and 12 months.

Methods: DNN models were constructed to predict post-discharge MACE across 4 categories. Multiple traditional machine learning models were implemented as controls to benchmark the performance of our DNN approach. All models were evaluated based on their ability to predict MACE occurrence during the specified follow-up periods.

Results: The DNN models demonstrated superior predictive performance over conventional machine learning methods, achieving high accuracies of 0.922, 0.884, and 0.913 for the 1-month, 6-month, and 12-month follow-up periods, respectively.

Conclusion: The high accuracy of our DNN models highlights their practical advantages for AMI diagnosis and guidance of follow-up treatment. These models can serve as valuable decision support tools, enabling clinicians to optimize the overall management of AMI patients and potentially enhance their hospitalization experience.