{"title":"舌鳞癌患者WPOI与临床病理参数的相关性研究。","authors":"Priyadharshini Muthumanickam, Gheena Sukumaran, Pratibha Ramani","doi":"10.4103/jomfp.jomfp_6_25","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the third most common head and neck malignancy, with tongue squamous cell carcinoma (TSCC) being highly aggressive due to its vascular and lymphatic supply. This study examines the correlation between the worst pattern of invasion (WPOI) and Ki-67 expression in TSCC to improve prognosis and treatment strategies.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 51 TSCC specimens (2021-2024) assessed clinicopathological data, WPOI classification, and Ki-67 expression using immunohistochemistry. Statistical correlations were evaluated.</p><p><strong>Results: </strong>The study showed a male predominance (mean age 53 years), with non-healing ulcers on the lateral tongue as the most common presentation. High-risk WPOI patterns correlated with advanced disease and metastasis (<i>P</i> < 0.001). Ki-67 expression averaged 45% in aggressive cases, but no significant correlation was found between WPOI and extranodal extension.</p><p><strong>Conclusion: </strong>WPOI and Ki-67 are crucial markers for TSCC aggressiveness, aiding in risk stratification and personalized treatment. Further validation in larger cohorts is needed.</p>","PeriodicalId":38846,"journal":{"name":"Journal of Oral and Maxillofacial Pathology","volume":"29 2","pages":"166-171"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283047/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation of the WPOI and clinicopathological parameters in tongue OSCC patients.\",\"authors\":\"Priyadharshini Muthumanickam, Gheena Sukumaran, Pratibha Ramani\",\"doi\":\"10.4103/jomfp.jomfp_6_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Oral squamous cell carcinoma (OSCC) is the third most common head and neck malignancy, with tongue squamous cell carcinoma (TSCC) being highly aggressive due to its vascular and lymphatic supply. This study examines the correlation between the worst pattern of invasion (WPOI) and Ki-67 expression in TSCC to improve prognosis and treatment strategies.</p><p><strong>Materials and methods: </strong>A retrospective analysis of 51 TSCC specimens (2021-2024) assessed clinicopathological data, WPOI classification, and Ki-67 expression using immunohistochemistry. Statistical correlations were evaluated.</p><p><strong>Results: </strong>The study showed a male predominance (mean age 53 years), with non-healing ulcers on the lateral tongue as the most common presentation. High-risk WPOI patterns correlated with advanced disease and metastasis (<i>P</i> < 0.001). Ki-67 expression averaged 45% in aggressive cases, but no significant correlation was found between WPOI and extranodal extension.</p><p><strong>Conclusion: </strong>WPOI and Ki-67 are crucial markers for TSCC aggressiveness, aiding in risk stratification and personalized treatment. Further validation in larger cohorts is needed.</p>\",\"PeriodicalId\":38846,\"journal\":{\"name\":\"Journal of Oral and Maxillofacial Pathology\",\"volume\":\"29 2\",\"pages\":\"166-171\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283047/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral and Maxillofacial Pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jomfp.jomfp_6_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral and Maxillofacial Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jomfp.jomfp_6_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/30 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Correlation of the WPOI and clinicopathological parameters in tongue OSCC patients.
Background: Oral squamous cell carcinoma (OSCC) is the third most common head and neck malignancy, with tongue squamous cell carcinoma (TSCC) being highly aggressive due to its vascular and lymphatic supply. This study examines the correlation between the worst pattern of invasion (WPOI) and Ki-67 expression in TSCC to improve prognosis and treatment strategies.
Materials and methods: A retrospective analysis of 51 TSCC specimens (2021-2024) assessed clinicopathological data, WPOI classification, and Ki-67 expression using immunohistochemistry. Statistical correlations were evaluated.
Results: The study showed a male predominance (mean age 53 years), with non-healing ulcers on the lateral tongue as the most common presentation. High-risk WPOI patterns correlated with advanced disease and metastasis (P < 0.001). Ki-67 expression averaged 45% in aggressive cases, but no significant correlation was found between WPOI and extranodal extension.
Conclusion: WPOI and Ki-67 are crucial markers for TSCC aggressiveness, aiding in risk stratification and personalized treatment. Further validation in larger cohorts is needed.
期刊介绍：
The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.
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