Alexandra Valetopoulou, Nicola Newall, Danyal Z Khan, Anouk Borg, Pierre M G Bouloux, Fion Bremner, Michael Buchfelder, Simon Cudlip, Neil Dorward, William M Drake, Juan C Fernandez-Miranda, Maria Fleseriu, Mathew Geltzeiler, Joy Ginn, Mark Gurnell, Steve Harris, Zane Jaunmuktane, Márta Korbonits, Michael Kosmin, Olympia Koulouri, Hugo Layard Horsfall, Adam N Mamelak, Richard Mannion, Pat McBride, Ann I McCormack, Shlomo Melmed, Katherine A Miszkiel, Gerald Raverot, Thomas Santarius, Theodore H Schwartz, Inma Serrano, Gabriel Zada, Stephanie E Baldeweg, Hani J Marcus, Angelos G Kolias
{"title":"垂体外科研究的核心结果集：一项国际德尔菲共识研究。","authors":"Alexandra Valetopoulou, Nicola Newall, Danyal Z Khan, Anouk Borg, Pierre M G Bouloux, Fion Bremner, Michael Buchfelder, Simon Cudlip, Neil Dorward, William M Drake, Juan C Fernandez-Miranda, Maria Fleseriu, Mathew Geltzeiler, Joy Ginn, Mark Gurnell, Steve Harris, Zane Jaunmuktane, Márta Korbonits, Michael Kosmin, Olympia Koulouri, Hugo Layard Horsfall, Adam N Mamelak, Richard Mannion, Pat McBride, Ann I McCormack, Shlomo Melmed, Katherine A Miszkiel, Gerald Raverot, Thomas Santarius, Theodore H Schwartz, Inma Serrano, Gabriel Zada, Stephanie E Baldeweg, Hani J Marcus, Angelos G Kolias","doi":"10.1007/s11102-025-01553-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.</p><p><strong>Methods: </strong>Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome's importance on a 5-point scale (1-strongly disagree; 5-strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3-4).</p><p><strong>Results: </strong>The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.</p><p><strong>Conclusion: </strong>We advocate for use of the COS in future pituitary surgery research.</p>","PeriodicalId":20202,"journal":{"name":"Pituitary","volume":"28 4","pages":"88"},"PeriodicalIF":3.4000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287136/pdf/","citationCount":"0","resultStr":"{\"title\":\"A core outcome set for pituitary surgery research: an international delphi consensus study.\",\"authors\":\"Alexandra Valetopoulou, Nicola Newall, Danyal Z Khan, Anouk Borg, Pierre M G Bouloux, Fion Bremner, Michael Buchfelder, Simon Cudlip, Neil Dorward, William M Drake, Juan C Fernandez-Miranda, Maria Fleseriu, Mathew Geltzeiler, Joy Ginn, Mark Gurnell, Steve Harris, Zane Jaunmuktane, Márta Korbonits, Michael Kosmin, Olympia Koulouri, Hugo Layard Horsfall, Adam N Mamelak, Richard Mannion, Pat McBride, Ann I McCormack, Shlomo Melmed, Katherine A Miszkiel, Gerald Raverot, Thomas Santarius, Theodore H Schwartz, Inma Serrano, Gabriel Zada, Stephanie E Baldeweg, Hani J Marcus, Angelos G Kolias\",\"doi\":\"10.1007/s11102-025-01553-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.</p><p><strong>Methods: </strong>Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome's importance on a 5-point scale (1-strongly disagree; 5-strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3-4).</p><p><strong>Results: </strong>The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). 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A core outcome set for pituitary surgery research: an international delphi consensus study.
Purpose: This study aimed to develop a core outcome set (COS) for pituitary surgery to enhance the quality, efficiency and effectiveness of future pituitary adenoma surgery research.
Methods: Thirty-three outcomes were identified through a systematic review of pituitary adenoma surgery outcomes and a study on patient-reported measures. These were presented in an online survey to healthcare professionals (HCPs), patients and caregivers. In the first round, participants scored each outcome's importance on a 5-point scale (1-strongly disagree; 5-strongly agree) and could also suggest additional outcomes, which were reviewed and, if appropriate, added to existing domains. In the second round, participants re-scored the updated the list, considering group median and interquartile range scores from the previous round. Outcomes with a median score of 5 were included in the COS. A final live online consensus meeting discussed and voted on borderline outcomes (median scores 3-4).
Results: The first round received 95 responses (52% HCPs, 48% patients/caregivers). Of the 33 outcomes, 16 received a median score of 5 (strongly agree), three received 4.5 and 14 received 4 (agree). Round two received 87 responses (52% HCPs, 48% patients and caregivers). Of the 33 outcomes, 14 received a median ranking of 5, two received 4.5, 15 received 4 and two received 3 (neutral). The live meeting (attended by 12 participants: 5 HCPs, 6 patients, 1 caregiver), reached consensus on the final COS, which includes 7 domains: short-term surgical outcomes; nasal outcomes; ophthalmic outcomes; endocrine outcomes; quality of life and psychological outcomes; other short-term outcomes; and disease control outcomes.
Conclusion: We advocate for use of the COS in future pituitary surgery research.
期刊介绍：
Pituitary is an international publication devoted to basic and clinical aspects of the pituitary gland. It is designed to publish original, high quality research in both basic and pituitary function as well as clinical pituitary disease.
The journal considers:
Biology of Pituitary Tumors
Mechanisms of Pituitary Hormone Secretion
Regulation of Pituitary Function
Prospective Clinical Studies of Pituitary Disease
Critical Basic and Clinical Reviews
Pituitary is directed at basic investigators, physiologists, clinical adult and pediatric endocrinologists, neurosurgeons and reproductive endocrinologists interested in the broad field of the pituitary and its disorders. The Editorial Board has been drawn from international experts in basic and clinical endocrinology. The journal offers a rapid turnaround time for review of manuscripts, and the high standard of the journal is maintained by a selective peer-review process which aims to publish only the highest quality manuscripts. Pituitary will foster the publication of creative scholarship as it pertains to the pituitary and will provide a forum for basic scientists and clinicians to publish their high quality pituitary-related work.
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