氯胺酮和其他NMDA受体拮抗剂后哺乳动物大脑中的高频振荡。

IF 5.5 3区 医学 Q1 CLINICAL NEUROLOGY
Mark Jeremy Hunt, Jacek Wróbel
{"title":"氯胺酮和其他NMDA受体拮抗剂后哺乳动物大脑中的高频振荡。","authors":"Mark Jeremy Hunt, Jacek Wróbel","doi":"10.1177/02698811251352454","DOIUrl":null,"url":null,"abstract":"<p><p>Subanesthetic doses of ketamine produce complex neuropsychiatric effects, which include rapid psychotomimetic symptoms and antidepressant effects that can last several weeks. Despite over 60 years of research, the mechanism(s) of action underlying ketamine's effects in the brain remains largely mysterious. Neurophysiological field potential recordings provide a direct window into brain activity, with different frequency bands reflecting functionally distinct neural networks. Two decades ago, we reported on the existence of high-frequency oscillations (HFO, >100 Hz) in freely moving rodents that were markedly enhanced by subanesthetic doses of ketamine. Since then, a large body of evidence has shown that HFO after ketamine (and other <i>N</i>-methyl-d-aspartate receptor (NMDAR) antagonists) are largely wake-related and prominent across diverse olfactory and frontostriatal brain regions. This rhythm, which is remarkably coherent across distinct regions, is modulated by slower oscillations with respiration-locked olfactory bulb activity a major driving force behind it. Similar activity has been reported in vivo in a variety of mammals with preclinical validity. This review is the first synthesis of studies reporting on the NMDAR antagonist-enhanced HFO rhythm. We identify current gaps and provide suggestions for future research, including the urgent need for more human studies.</p>","PeriodicalId":16892,"journal":{"name":"Journal of Psychopharmacology","volume":" ","pages":"2698811251352454"},"PeriodicalIF":5.5000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-frequency oscillations in the mammalian brain after ketamine and other NMDA receptor antagonists.\",\"authors\":\"Mark Jeremy Hunt, Jacek Wróbel\",\"doi\":\"10.1177/02698811251352454\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Subanesthetic doses of ketamine produce complex neuropsychiatric effects, which include rapid psychotomimetic symptoms and antidepressant effects that can last several weeks. Despite over 60 years of research, the mechanism(s) of action underlying ketamine's effects in the brain remains largely mysterious. Neurophysiological field potential recordings provide a direct window into brain activity, with different frequency bands reflecting functionally distinct neural networks. Two decades ago, we reported on the existence of high-frequency oscillations (HFO, >100 Hz) in freely moving rodents that were markedly enhanced by subanesthetic doses of ketamine. Since then, a large body of evidence has shown that HFO after ketamine (and other <i>N</i>-methyl-d-aspartate receptor (NMDAR) antagonists) are largely wake-related and prominent across diverse olfactory and frontostriatal brain regions. This rhythm, which is remarkably coherent across distinct regions, is modulated by slower oscillations with respiration-locked olfactory bulb activity a major driving force behind it. Similar activity has been reported in vivo in a variety of mammals with preclinical validity. This review is the first synthesis of studies reporting on the NMDAR antagonist-enhanced HFO rhythm. We identify current gaps and provide suggestions for future research, including the urgent need for more human studies.</p>\",\"PeriodicalId\":16892,\"journal\":{\"name\":\"Journal of Psychopharmacology\",\"volume\":\" \",\"pages\":\"2698811251352454\"},\"PeriodicalIF\":5.5000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/02698811251352454\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/02698811251352454","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

亚麻醉剂量的氯胺酮产生复杂的神经精神作用,包括快速的拟精神症状和可持续数周的抗抑郁作用。尽管经过了60多年的研究,氯胺酮在大脑中的作用机制在很大程度上仍然是一个谜。神经生理场电位记录为大脑活动提供了一个直接的窗口,不同的频段反映了功能不同的神经网络。二十年前,我们报道了在自由活动的啮齿动物中存在高频振荡(HFO, bbb100 Hz),亚麻醉剂量的氯胺酮显著增强了这种振荡。从那时起,大量证据表明氯胺酮(和其他n -甲基-d-天冬氨酸受体(NMDAR)拮抗剂)后的HFO主要与清醒相关,并在不同的嗅觉和额纹状体脑区突出。这种节奏在不同的区域之间具有显著的一致性,是由呼吸锁定嗅球活动的较慢振荡调节的。在多种哺乳动物体内也有类似的活性,具有临床前有效性。这篇综述是首次综合报道NMDAR拮抗剂增强HFO节律的研究。我们确定当前的差距,并为未来的研究提供建议,包括迫切需要更多的人体研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-frequency oscillations in the mammalian brain after ketamine and other NMDA receptor antagonists.

Subanesthetic doses of ketamine produce complex neuropsychiatric effects, which include rapid psychotomimetic symptoms and antidepressant effects that can last several weeks. Despite over 60 years of research, the mechanism(s) of action underlying ketamine's effects in the brain remains largely mysterious. Neurophysiological field potential recordings provide a direct window into brain activity, with different frequency bands reflecting functionally distinct neural networks. Two decades ago, we reported on the existence of high-frequency oscillations (HFO, >100 Hz) in freely moving rodents that were markedly enhanced by subanesthetic doses of ketamine. Since then, a large body of evidence has shown that HFO after ketamine (and other N-methyl-d-aspartate receptor (NMDAR) antagonists) are largely wake-related and prominent across diverse olfactory and frontostriatal brain regions. This rhythm, which is remarkably coherent across distinct regions, is modulated by slower oscillations with respiration-locked olfactory bulb activity a major driving force behind it. Similar activity has been reported in vivo in a variety of mammals with preclinical validity. This review is the first synthesis of studies reporting on the NMDAR antagonist-enhanced HFO rhythm. We identify current gaps and provide suggestions for future research, including the urgent need for more human studies.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Psychopharmacology
Journal of Psychopharmacology 医学-精神病学
CiteScore
8.60
自引率
4.90%
发文量
126
审稿时长
3-8 weeks
期刊介绍: The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信