儿童恶性肿瘤高钙血症:通过病例系列探讨临床挑战。

IF 0.8 4区 医学 Q4 HEMATOLOGY
Alpas Anand, Neha Goel, Amitabh Singh, Prashant Prabhakar, Meghna Kumari, Hashmat Singh, Suruchi Viz, Nidhi Chopra, Sumit Mehndiratta
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引用次数: 0

摘要

背景:高钙血症是儿科恶性肿瘤的一种罕见但临床上重要的并发症,通常表现为症状。然而,在这个病例系列中,我们报告了4例在白血病诊断时通过常规生化评估偶然发现的非特异性高钙血症症状的儿童。病例描述:患者,5 - 9岁,有潜在的恶性肿瘤,包括霍奇金淋巴瘤(IIA期),前b细胞急性淋巴细胞白血病和急性早幼粒细胞白血病。所有患者均出现严重高钙血症,需要及时干预。治疗包括高水合,循环利尿剂,双膦酸盐和降钙素,以及潜在的恶性肿瘤的管理。所有病例均成功解决高钙血症,无复发。结论:本病例系列强调了常规生化筛查对新诊断的儿童恶性肿瘤的重要性,特别是对高钙血症的非特异性症状,否则可能无法识别。尽管血液学恶性肿瘤中的高钙血症有充分的文献记载,但我们的研究结果强调了沉默的表现,并强调了早期识别以避免代谢并发症的临床需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypercalcemia of Malignancy in Pediatric Population: Clinical Challenges Explored Through Cases-A Case Series.

Background: Hypercalcemia is an uncommon but clinically significant complication of pediatric malignancies that often presents with symptoms. However, in this case series, we report 4 children with nonspecific symptoms of hypercalcemia detected incidentally on routine biochemical evaluation at the time of leukemia diagnosis.

Case presentation: Patients, 5 to 9 years of age, had underlying malignancies, including Hodgkin lymphoma (stage IIA), pre-B-cell acute lymphoblastic leukemia, and acute promyelocytic leukemia. All the patients presented with severe hypercalcemia, necessitating prompt intervention. Treatment consisted of hyperhydration, loop diuretics, bisphosphonates, and calcitonin, along with the management of the underlying malignancy. Successful resolution of hypercalcemia was achieved in all cases, with no future recurrence.

Conclusion: This case series highlights the importance of the routine biochemical screening for newly diagnosed pediatric malignancies, particularly for nonspecific symptoms of hypercalcemia, which may otherwise go unrecognized. Although hypercalcemia in hematological malignancies is well-documented, our findings stress the silent presentation and reinforce the clinical need for early identification to avoid metabolic complications.

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来源期刊
CiteScore
1.90
自引率
8.30%
发文量
415
审稿时长
2.5 months
期刊介绍: ​Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.
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