{"title":"血浆高动脉粥样硬化指数与肺功能受损之间的关系：一项基于人群的研究。","authors":"Liang Yang, Yuanzhou Wu, Ling Chen, Zizhao Li, Wenfei Zhu, Ziyan Zhang, Hui Li, Yang Huang, Qunqing Chen","doi":"10.3389/fmed.2025.1589605","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Although AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.</p><p><strong>Methods: </strong>Data from 4,565 participants in the NHANES 2007-2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV<sub>1</sub>, FVC, and FEV<sub>1</sub>/FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.</p><p><strong>Results: </strong>Multivariable regression showed a significant negative association between AIP and FEV<sub>1</sub> (β = -121.3 mL/unit, <i>p</i> < 0.001) and FVC (β = -147.1 mL/unit, <i>p</i> < 0.001), with no significant link to FEV<sub>1</sub>/FVC ratio. Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV<sub>1</sub>) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.</p><p><strong>Conclusion: </strong>Elevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. These findings support AIP as a potential adjunct marker for pulmonary function assessment in clinical practice.</p>","PeriodicalId":12488,"journal":{"name":"Frontiers in Medicine","volume":"12 ","pages":"1589605"},"PeriodicalIF":3.1000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283284/pdf/","citationCount":"0","resultStr":"{\"title\":\"The association between high atherogenic index of plasma and impaired lung function: a population-based study.\",\"authors\":\"Liang Yang, Yuanzhou Wu, Ling Chen, Zizhao Li, Wenfei Zhu, Ziyan Zhang, Hui Li, Yang Huang, Qunqing Chen\",\"doi\":\"10.3389/fmed.2025.1589605\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Although AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.</p><p><strong>Methods: </strong>Data from 4,565 participants in the NHANES 2007-2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV<sub>1</sub>, FVC, and FEV<sub>1</sub>/FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.</p><p><strong>Results: </strong>Multivariable regression showed a significant negative association between AIP and FEV<sub>1</sub> (β = -121.3 mL/unit, <i>p</i> < 0.001) and FVC (β = -147.1 mL/unit, <i>p</i> < 0.001), with no significant link to FEV<sub>1</sub>/FVC ratio. Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV<sub>1</sub>) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.</p><p><strong>Conclusion: </strong>Elevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. 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引用次数: 0
摘要
目的：虽然AIP是公认的心血管危险标志物，但其与肺功能和性别差异的关系尚不清楚。这项研究调查了AIP升高是否与肺功能降低独立相关，并检查了潜在的性别特异性模式。方法：采用横断面设计对NHANES 2007-2012数据集中4565名参与者的数据进行分析。AIP作为暴露变量，以5个肺功能指标（包括FEV1、FVC和FEV1/FVC比率）作为结果。采用加权多元线性回归、阈值效应分析、亚组比较和XGBoost建模来评估相关性。结果：多变量回归显示AIP与FEV1 （β = -121.3 mL/unit, p < 0.001）和FVC （β = -147.1 mL/unit, p < 0.001）呈显著负相关，与FEV1/FVC比值无显著相关性。亚组分析显示，女性呈u型非线性关联，AIP值为0.77 （FEV1）和0.78 （FVC）时出现拐点，超过该拐点肺功能下降趋于稳定。男性在所有AIP水平上表现出一致的负相关。结论：AIP升高与肺功能降低独立相关，尤其是女性的非线性效应。这些发现支持AIP在临床实践中作为肺功能评估的潜在辅助标志物。
The association between high atherogenic index of plasma and impaired lung function: a population-based study.
Objective: Although AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.
Methods: Data from 4,565 participants in the NHANES 2007-2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV1, FVC, and FEV1/FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.
Results: Multivariable regression showed a significant negative association between AIP and FEV1 (β = -121.3 mL/unit, p < 0.001) and FVC (β = -147.1 mL/unit, p < 0.001), with no significant link to FEV1/FVC ratio. Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV1) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.
Conclusion: Elevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. These findings support AIP as a potential adjunct marker for pulmonary function assessment in clinical practice.
期刊介绍：
Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate
- the use of patient-reported outcomes under real world conditions
- the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines
- the scientific bases for guidelines and decisions from regulatory authorities
- access to medicinal products and medical devices worldwide
- addressing the grand health challenges around the world
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