Yong-Wang Zhang, Pei-Yu Du, Xi Li, Lu Liu, Yun-Tao Yan, Yi-Cong Bai, Xin-Yu Tian, Shuang-Qing Du
{"title":"膝关节骨性关节炎患者腰冠状位水平移位与下肢力线的相关性研究。","authors":"Yong-Wang Zhang, Pei-Yu Du, Xi Li, Lu Liu, Yun-Tao Yan, Yi-Cong Bai, Xin-Yu Tian, Shuang-Qing Du","doi":"10.3389/fbioe.2025.1600020","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to explore the correlation between the horizontal deviation of the coronal lumbar spine and the lower limb force line in knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>A retrospective analysis of 233 KOA cases (47 male patients and 186 female patients, aged 50-83 years, with an average of 61.55 ± 8.72 years) admitted from 1 October 2022 to 31 December 2023 was conducted. Bilateral hip, knee, and ankle (HKA) angles; mechanical axis offset distance (MAD); joint line convergence angle (JLCA); lumbar-knee offset distance (LKOD, a self-tested angle reflecting the difference in the position of the bilateral knee joint relative to the lumbar vertebra); Western Ontario and McMaster Universities Arthritis Index (WOMAC) score; and baseline data records were assessed for all patients.</p><p><strong>Results: </strong>The WOMAC score was correlated with L1, L2, and L3 in LKOD (<i>P</i> < 0.05; r = 0.240, 0.362, and 0.386) but not with L4 and L5 (<i>P</i> > 0.05). WOMAC was also associated with HKA, MAD, and JLCA on the affected side (<i>P</i> < 0.05; r = -0.127, 0.140, and 0.135). The unaffected side and d-values were not associated with HKA, MAD, and JLCA (the d-value represents the absolute value of the difference between the unaffected and affected sides, which represents the overall change in both lower limbs) (<i>P</i> > 0.05). L1-L5 in LKOD was associated with HKA and MAD d-values (<i>P</i> < 0.05); LKOD was not correlated with HKA, MAD, and JLCA on the affected side.</p><p><strong>Conclusion: </strong>Lumbar horizontal deviation is a risk factor affecting all angles in both lower limbs and may aggravate knee bone and joint symptoms. The influence of horizontal direction changes in the lumbar spine on KOA, especially change in L3, should be prioritized in the clinical treatment and research of KOA.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1600020"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283583/pdf/","citationCount":"0","resultStr":"{\"title\":\"Coronal lumbar horizontal shift and lower limb force line in patients with knee osteoarthritis: a correlation study.\",\"authors\":\"Yong-Wang Zhang, Pei-Yu Du, Xi Li, Lu Liu, Yun-Tao Yan, Yi-Cong Bai, Xin-Yu Tian, Shuang-Qing Du\",\"doi\":\"10.3389/fbioe.2025.1600020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim of this study is to explore the correlation between the horizontal deviation of the coronal lumbar spine and the lower limb force line in knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>A retrospective analysis of 233 KOA cases (47 male patients and 186 female patients, aged 50-83 years, with an average of 61.55 ± 8.72 years) admitted from 1 October 2022 to 31 December 2023 was conducted. Bilateral hip, knee, and ankle (HKA) angles; mechanical axis offset distance (MAD); joint line convergence angle (JLCA); lumbar-knee offset distance (LKOD, a self-tested angle reflecting the difference in the position of the bilateral knee joint relative to the lumbar vertebra); Western Ontario and McMaster Universities Arthritis Index (WOMAC) score; and baseline data records were assessed for all patients.</p><p><strong>Results: </strong>The WOMAC score was correlated with L1, L2, and L3 in LKOD (<i>P</i> < 0.05; r = 0.240, 0.362, and 0.386) but not with L4 and L5 (<i>P</i> > 0.05). WOMAC was also associated with HKA, MAD, and JLCA on the affected side (<i>P</i> < 0.05; r = -0.127, 0.140, and 0.135). The unaffected side and d-values were not associated with HKA, MAD, and JLCA (the d-value represents the absolute value of the difference between the unaffected and affected sides, which represents the overall change in both lower limbs) (<i>P</i> > 0.05). L1-L5 in LKOD was associated with HKA and MAD d-values (<i>P</i> < 0.05); LKOD was not correlated with HKA, MAD, and JLCA on the affected side.</p><p><strong>Conclusion: </strong>Lumbar horizontal deviation is a risk factor affecting all angles in both lower limbs and may aggravate knee bone and joint symptoms. The influence of horizontal direction changes in the lumbar spine on KOA, especially change in L3, should be prioritized in the clinical treatment and research of KOA.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1600020\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283583/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1600020\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1600020","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Coronal lumbar horizontal shift and lower limb force line in patients with knee osteoarthritis: a correlation study.
Objective: The aim of this study is to explore the correlation between the horizontal deviation of the coronal lumbar spine and the lower limb force line in knee osteoarthritis (KOA).
Methods: A retrospective analysis of 233 KOA cases (47 male patients and 186 female patients, aged 50-83 years, with an average of 61.55 ± 8.72 years) admitted from 1 October 2022 to 31 December 2023 was conducted. Bilateral hip, knee, and ankle (HKA) angles; mechanical axis offset distance (MAD); joint line convergence angle (JLCA); lumbar-knee offset distance (LKOD, a self-tested angle reflecting the difference in the position of the bilateral knee joint relative to the lumbar vertebra); Western Ontario and McMaster Universities Arthritis Index (WOMAC) score; and baseline data records were assessed for all patients.
Results: The WOMAC score was correlated with L1, L2, and L3 in LKOD (P < 0.05; r = 0.240, 0.362, and 0.386) but not with L4 and L5 (P > 0.05). WOMAC was also associated with HKA, MAD, and JLCA on the affected side (P < 0.05; r = -0.127, 0.140, and 0.135). The unaffected side and d-values were not associated with HKA, MAD, and JLCA (the d-value represents the absolute value of the difference between the unaffected and affected sides, which represents the overall change in both lower limbs) (P > 0.05). L1-L5 in LKOD was associated with HKA and MAD d-values (P < 0.05); LKOD was not correlated with HKA, MAD, and JLCA on the affected side.
Conclusion: Lumbar horizontal deviation is a risk factor affecting all angles in both lower limbs and may aggravate knee bone and joint symptoms. The influence of horizontal direction changes in the lumbar spine on KOA, especially change in L3, should be prioritized in the clinical treatment and research of KOA.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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