{"title":"产gla生物的研究进展及未来发展方向。","authors":"Mojgan Latifi, Foroozan Jalali Bidgoli, Helia Hajihassani, Danial Hassani, Pär K Ingvarsson, Naser Farrokhi","doi":"10.3389/fbioe.2025.1567840","DOIUrl":null,"url":null,"abstract":"<p><p>Gamma-linolenic acid (GLA) is a biologically active omega-6 fatty acid with anti-inflammatory, immunomodulatory, and cardiovascular protective effects. It is a vital constituent of human health and is finding more widespread applications in nutritional supplements, medications, and functional foods. GLA can be derived from many different natural sources, including plants, fungi, and microorganisms. This review paper presents an overview of the current advances in the discovery, metabolic engineering, and GLA-producing organism optimization. We further present a discussion on new biotechnological approaches-such as culture medium optimization, genetic engineering, and genome editing-that can be employed to enhance GLA production. The paper also presents new trends and directions in the commercial exploitation of GLA-containing products, unveiling new, health-oriented applications.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1567840"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283596/pdf/","citationCount":"0","resultStr":"{\"title\":\"Recent advances and future directions on GLA-producing organisms.\",\"authors\":\"Mojgan Latifi, Foroozan Jalali Bidgoli, Helia Hajihassani, Danial Hassani, Pär K Ingvarsson, Naser Farrokhi\",\"doi\":\"10.3389/fbioe.2025.1567840\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Gamma-linolenic acid (GLA) is a biologically active omega-6 fatty acid with anti-inflammatory, immunomodulatory, and cardiovascular protective effects. It is a vital constituent of human health and is finding more widespread applications in nutritional supplements, medications, and functional foods. GLA can be derived from many different natural sources, including plants, fungi, and microorganisms. This review paper presents an overview of the current advances in the discovery, metabolic engineering, and GLA-producing organism optimization. We further present a discussion on new biotechnological approaches-such as culture medium optimization, genetic engineering, and genome editing-that can be employed to enhance GLA production. The paper also presents new trends and directions in the commercial exploitation of GLA-containing products, unveiling new, health-oriented applications.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1567840\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283596/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1567840\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1567840","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Recent advances and future directions on GLA-producing organisms.
Gamma-linolenic acid (GLA) is a biologically active omega-6 fatty acid with anti-inflammatory, immunomodulatory, and cardiovascular protective effects. It is a vital constituent of human health and is finding more widespread applications in nutritional supplements, medications, and functional foods. GLA can be derived from many different natural sources, including plants, fungi, and microorganisms. This review paper presents an overview of the current advances in the discovery, metabolic engineering, and GLA-producing organism optimization. We further present a discussion on new biotechnological approaches-such as culture medium optimization, genetic engineering, and genome editing-that can be employed to enhance GLA production. The paper also presents new trends and directions in the commercial exploitation of GLA-containing products, unveiling new, health-oriented applications.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.