eb病毒的免疫逃避。

3区医学 Q2 Medicine

Current topics in microbiology and immunology Pub Date : 2025-07-25 DOI:10.1007/82_2025_311

Jianmin Zuo, Dong-Yan Jin

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引用次数: 0

摘要

爱泼斯坦-巴尔病毒（EBV）感染了全球90%以上的成年人。在初始感染后，宿主免疫系统启动涉及先天和适应性免疫功能的抗病毒反应。EBV建立了持久的、终身的感染，为了实现这一点，它必须仔细调节宿主的免疫反应。通过在病毒复制和免疫防御之间取得平衡，EBV的致病作用最小化，同时保持其存在。本章探讨了EBV采用的一些免疫调节策略，特别是它对先天免疫和适应性免疫各分支的干扰，包括MHC-I和MHC-II抗原递呈途径。

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Immune Evasion by Epstein-Barr Virus.

Epstein-Barr virus (EBV) infects more than 90% of adults worldwide. Following the initial infection, the host immune system launches an antiviral response involving both innate and adaptive immune functions. EBV establishes a persistent, lifelong infection, and to achieve this, it must carefully regulate the host immune response. By striking a balance between viral replication and immune defense, the pathogenic effects of EBV are minimized while its presence is maintained. This chapter explores some of the immune-modulating strategies employed by EBV, particularly its interference with various arms of innate and adaptive immunity, including the MHC-I and MHC-II antigen presentation pathways.

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来源期刊

Current topics in microbiology and immunology 医学-免疫学

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The review series Current Topics in Microbiology and Immunology provides a synthesis of the latest research findings in the areas of molecular immunology, bacteriology and virology. Each timely volume contains a wealth of information on the featured subject. This review series is designed to provide access to up-to-date, often previously unpublished information.