铜（II）催化下芳基乙酸衍生物的位点选择性C(sp3)-H胺化反应。

IF 2.7 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-07-24 DOI:10.1039/d5ob00787a

Arun Kumar Hajra, Prasanjit Ghosh, Chandreyee Roy, Mrinalkanti Kundu, Sajal Das

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引用次数: 0

摘要

以游离环/无环仲胺和8-氨基咪唑[1,2- A吡啶]（8-AIP）为双齿螯合助剂，成功地建立了铜（II）催化（Het）芳基乙酰胺衍生物的交叉脱氢（CDC）工艺。该方法在空气存在下具有良好的官能团相容性，具有广泛的衬底范围。此外，通过合成衍生物的后多样化展示了该新协议的合成适应性。

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Site-selective C(sp³)-H amination of (het)aryl acetic acid derivatives under copper(II) catalysis.

A ubiquitous copper(II) catalyzed cross-dehydrogenative (CDC) process of (Het)arylacetamide derivatives employing free cyclic/acyclic secondary amines with the aid of 8-aminoimidazo[1,2-a pyridine] (8-AIP) as a bidentate chelating auxiliary has been successfully developed. This methodology exhibits a broad substrate scope with good functional group compatibility in the presence of air. Furthermore, the synthetic adaptability of this novel protocol is showcased through the post-diversification of synthesized derivatives.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.