{"title":"癌症儿童兄弟姐妹的不良身体健康结果和医疗服务利用：一项系统综述","authors":"Victorine Sirveaux, Lily Puterman-Salzman, Yue Qian Zhang, Eleni Sotirakos, Philippe Dodin, Guillaume Dumas, Eyal Cohen, Nadia Roumeliotis, Petros Pechlivanoglou, Hallie Coltin","doi":"10.1002/cam4.71035","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Siblings of children with cancer may be vulnerable to compromised long-term health. We aimed to describe the frequency (prevalence, incidence) of adverse physical health outcomes and healthcare service utilization among siblings of children with cancer and compare the risk of the above outcomes to siblings of children without cancer.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We searched Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Clarivate Web of Science through June 15, 2024. We included English and French-language studies, both with and without a healthy control population, that reported adverse physical health outcomes and/or healthcare service utilization outcomes among siblings of children with cancer. Studies focusing exclusively on mental health or quality of life were excluded. Abstracts were screened by two reviewers; full-text articles underwent data abstraction and risk of bias assessment. Results were synthesized descriptively.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Of 26,570 studies screened, 44 were included. Heterogeneity was observed in all reported outcomes: mortality; cancer; organ system disease; overweight/obesity; pain; congenital anomalies; comorbidities; infections; amputations; adverse health behavior (smoking, alcohol consumption); infertility; healthcare service utilization (hospitalization, emergency department/urgent care visits, prescriptions). We detected a trend toward increased risk of cancer, hospitalizations, and prescription medication use compared to control siblings. Significant study heterogeneity rendered meta-analyses inappropriate.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Siblings of children with cancer are likely vulnerable to various adverse health outcomes. However, the published literature is widely heterogeneous regarding study design, populations, and outcomes measurements, limiting our comprehensive analysis of risk. Future research with homogenized methodology is needed to better quantify risk, which would inform targeted surveillance guidelines and interventions.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 15","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.71035","citationCount":"0","resultStr":"{\"title\":\"Adverse Physical Health Outcomes and Healthcare Service Utilization in Siblings of Children With Cancer: A Systematic Review\",\"authors\":\"Victorine Sirveaux, Lily Puterman-Salzman, Yue Qian Zhang, Eleni Sotirakos, Philippe Dodin, Guillaume Dumas, Eyal Cohen, Nadia Roumeliotis, Petros Pechlivanoglou, Hallie Coltin\",\"doi\":\"10.1002/cam4.71035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Siblings of children with cancer may be vulnerable to compromised long-term health. 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引用次数: 0
摘要
患有癌症的儿童的兄弟姐妹可能容易受到长期健康损害。我们的目的是描述癌症儿童的兄弟姐妹中不良身体健康结果和医疗保健服务利用的频率（流行率、发生率），并比较上述结果与非癌症儿童的兄弟姐妹的风险。方法检索到2024年6月15日的Ovid MEDLINE、Embase、Cochrane Central Register of Controlled Trials、CINAHL和Clarivate Web of Science。我们纳入了有或没有健康对照人群的英语和法语研究，这些研究报告了癌症儿童的兄弟姐妹中不良的身体健康结果和/或医疗保健服务利用结果。只关注心理健康或生活质量的研究被排除在外。摘要由两位审稿人筛选；全文文章进行数据提取和偏倚风险评估。结果进行描述性综合。结果在筛选的26,570项研究中，有44项被纳入。所有报告的结果均存在异质性：死亡率；癌症;器官系统疾病；超重/肥胖;疼痛;先天性异常;并发症;感染;截肢;不良健康行为（吸烟、饮酒）；不孕症;保健服务的利用（住院、急诊科/紧急护理就诊、处方）。与对照组相比，我们发现了癌症、住院和处方药使用风险增加的趋势。显著的研究异质性使得meta分析不合适。结论癌症患儿的兄弟姐妹可能易受各种不良健康结果的影响。然而，已发表的文献在研究设计、人群和结果测量方面存在广泛的异质性，限制了我们对风险的综合分析。未来需要采用同质化方法进行研究，以便更好地量化风险，从而为有针对性的监测指南和干预措施提供信息。
Adverse Physical Health Outcomes and Healthcare Service Utilization in Siblings of Children With Cancer: A Systematic Review
Introduction
Siblings of children with cancer may be vulnerable to compromised long-term health. We aimed to describe the frequency (prevalence, incidence) of adverse physical health outcomes and healthcare service utilization among siblings of children with cancer and compare the risk of the above outcomes to siblings of children without cancer.
Methods
We searched Ovid MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CINAHL, and Clarivate Web of Science through June 15, 2024. We included English and French-language studies, both with and without a healthy control population, that reported adverse physical health outcomes and/or healthcare service utilization outcomes among siblings of children with cancer. Studies focusing exclusively on mental health or quality of life were excluded. Abstracts were screened by two reviewers; full-text articles underwent data abstraction and risk of bias assessment. Results were synthesized descriptively.
Results
Of 26,570 studies screened, 44 were included. Heterogeneity was observed in all reported outcomes: mortality; cancer; organ system disease; overweight/obesity; pain; congenital anomalies; comorbidities; infections; amputations; adverse health behavior (smoking, alcohol consumption); infertility; healthcare service utilization (hospitalization, emergency department/urgent care visits, prescriptions). We detected a trend toward increased risk of cancer, hospitalizations, and prescription medication use compared to control siblings. Significant study heterogeneity rendered meta-analyses inappropriate.
Conclusions
Siblings of children with cancer are likely vulnerable to various adverse health outcomes. However, the published literature is widely heterogeneous regarding study design, populations, and outcomes measurements, limiting our comprehensive analysis of risk. Future research with homogenized methodology is needed to better quantify risk, which would inform targeted surveillance guidelines and interventions.
期刊介绍：
Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas:
Clinical Cancer Research
Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations
Cancer Biology:
Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery.
Cancer Prevention:
Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach.
Bioinformatics:
Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers.
Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.
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