Li-Kun Ge , Shu Zhang , Li-Zhen Chen , Ke Zhou , Li Zhang , Xi-Nian Zuo , Gao-Xia Wei , Jingang Dai
{"title":"改善你的情绪:运动和杏仁核如何一起跳舞","authors":"Li-Kun Ge , Shu Zhang , Li-Zhen Chen , Ke Zhou , Li Zhang , Xi-Nian Zuo , Gao-Xia Wei , Jingang Dai","doi":"10.1016/j.ijchp.2025.100610","DOIUrl":null,"url":null,"abstract":"<div><div>Accumulative evidence has shown that functional heterogeneity exists in subregions of amygdala. Recently, exercise serving as automatic emotion regulation has been observed to induce the altered activation of amygdala associated with mood change. However, the specific role of subregions of amygdala underlying these effects are not fully understood. By using resting-state functional magnetic resonance imaging (rs-fMRI), this study examined whether the subregions of amygdala play distinct roles in mood improvement induced by acute exercise.</div><div>Participants (<em>n</em> = 76) aged 18–22 were recruited and randomly divided into the exercise group and the control group. The exercise group received a 30-minute intervention with moderate-intensity exercise while the control group completed a reading control task at resting state. Whole-brain rs-fMRI scans were conducted before and after the interventions. Moreover, participants’ moods were also assessed using the Positive and Negative Affect Schedule (PANAS) and Abbreviated Profile of Mood States. A mixed-effect model was used to analyze the Group × Time interaction on functional connectivity (FC) seeded from medial amygdala (mAmyg) and lateral amygdala (lAmyg) subregions in each hemisphere.</div><div>Results revealed that exercise-induced mood improvements were correlated with significant Group × Time interaction effects on FC, showing a notable right-hemispheric predominance. Specifically, enhanced connectivity of the right mAmyg with orbitofrontal cortex, parietal, and cerebellar regions was associated with reduced negative affect and increased self-esteem. Concurrently, enhanced connectivity of the right lAmyg with the orbitofrontal cortex and striatum was linked to a broad spectrum of improvements, including reduced tension and anger, and increased vigor.</div><div>These findings suggest that acute exercise improves mood via distinct, lateralized neural pathways centered on different amygdala subregions. The mAmyg and lAmyg play complementary roles in automatic emotion regulation, with the right mAmyg modulating affective valence and self-evaluation, while the right lAmyg appears to regulate a broad spectrum of mood states and enhance positive arousal. This work provides a more nuanced neurobiological model for the therapeutic effects of exercise.</div></div>","PeriodicalId":47673,"journal":{"name":"International Journal of Clinical and Health Psychology","volume":"25 3","pages":"Article 100610"},"PeriodicalIF":4.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Boosting your mood: How exercise and the amygdala dance together\",\"authors\":\"Li-Kun Ge , Shu Zhang , Li-Zhen Chen , Ke Zhou , Li Zhang , Xi-Nian Zuo , Gao-Xia Wei , Jingang Dai\",\"doi\":\"10.1016/j.ijchp.2025.100610\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Accumulative evidence has shown that functional heterogeneity exists in subregions of amygdala. Recently, exercise serving as automatic emotion regulation has been observed to induce the altered activation of amygdala associated with mood change. However, the specific role of subregions of amygdala underlying these effects are not fully understood. By using resting-state functional magnetic resonance imaging (rs-fMRI), this study examined whether the subregions of amygdala play distinct roles in mood improvement induced by acute exercise.</div><div>Participants (<em>n</em> = 76) aged 18–22 were recruited and randomly divided into the exercise group and the control group. The exercise group received a 30-minute intervention with moderate-intensity exercise while the control group completed a reading control task at resting state. Whole-brain rs-fMRI scans were conducted before and after the interventions. Moreover, participants’ moods were also assessed using the Positive and Negative Affect Schedule (PANAS) and Abbreviated Profile of Mood States. A mixed-effect model was used to analyze the Group × Time interaction on functional connectivity (FC) seeded from medial amygdala (mAmyg) and lateral amygdala (lAmyg) subregions in each hemisphere.</div><div>Results revealed that exercise-induced mood improvements were correlated with significant Group × Time interaction effects on FC, showing a notable right-hemispheric predominance. Specifically, enhanced connectivity of the right mAmyg with orbitofrontal cortex, parietal, and cerebellar regions was associated with reduced negative affect and increased self-esteem. Concurrently, enhanced connectivity of the right lAmyg with the orbitofrontal cortex and striatum was linked to a broad spectrum of improvements, including reduced tension and anger, and increased vigor.</div><div>These findings suggest that acute exercise improves mood via distinct, lateralized neural pathways centered on different amygdala subregions. The mAmyg and lAmyg play complementary roles in automatic emotion regulation, with the right mAmyg modulating affective valence and self-evaluation, while the right lAmyg appears to regulate a broad spectrum of mood states and enhance positive arousal. This work provides a more nuanced neurobiological model for the therapeutic effects of exercise.</div></div>\",\"PeriodicalId\":47673,\"journal\":{\"name\":\"International Journal of Clinical and Health Psychology\",\"volume\":\"25 3\",\"pages\":\"Article 100610\"},\"PeriodicalIF\":4.4000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Clinical and Health Psychology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1697260025000675\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, CLINICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Clinical and Health Psychology","FirstCategoryId":"102","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1697260025000675","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, CLINICAL","Score":null,"Total":0}
Boosting your mood: How exercise and the amygdala dance together
Accumulative evidence has shown that functional heterogeneity exists in subregions of amygdala. Recently, exercise serving as automatic emotion regulation has been observed to induce the altered activation of amygdala associated with mood change. However, the specific role of subregions of amygdala underlying these effects are not fully understood. By using resting-state functional magnetic resonance imaging (rs-fMRI), this study examined whether the subregions of amygdala play distinct roles in mood improvement induced by acute exercise.
Participants (n = 76) aged 18–22 were recruited and randomly divided into the exercise group and the control group. The exercise group received a 30-minute intervention with moderate-intensity exercise while the control group completed a reading control task at resting state. Whole-brain rs-fMRI scans were conducted before and after the interventions. Moreover, participants’ moods were also assessed using the Positive and Negative Affect Schedule (PANAS) and Abbreviated Profile of Mood States. A mixed-effect model was used to analyze the Group × Time interaction on functional connectivity (FC) seeded from medial amygdala (mAmyg) and lateral amygdala (lAmyg) subregions in each hemisphere.
Results revealed that exercise-induced mood improvements were correlated with significant Group × Time interaction effects on FC, showing a notable right-hemispheric predominance. Specifically, enhanced connectivity of the right mAmyg with orbitofrontal cortex, parietal, and cerebellar regions was associated with reduced negative affect and increased self-esteem. Concurrently, enhanced connectivity of the right lAmyg with the orbitofrontal cortex and striatum was linked to a broad spectrum of improvements, including reduced tension and anger, and increased vigor.
These findings suggest that acute exercise improves mood via distinct, lateralized neural pathways centered on different amygdala subregions. The mAmyg and lAmyg play complementary roles in automatic emotion regulation, with the right mAmyg modulating affective valence and self-evaluation, while the right lAmyg appears to regulate a broad spectrum of mood states and enhance positive arousal. This work provides a more nuanced neurobiological model for the therapeutic effects of exercise.
期刊介绍:
The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.