NH4I/ thbhp介导2-氨基噻吩和芳基甲基酮[4 + 1]氧化环合成2-芳基苯并噻唑

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-07-24 DOI:10.1016/j.tetlet.2025.155750

Sasi Sree Marupalli, Venkatachalam Rajeshkumar

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引用次数: 0

摘要

采用NH4I/ thbhp体系，建立了一锅法合成2-芳基苯并噻唑的高效工艺。反应通过NH4I/ thbhp介导的芳基甲基酮的氧化进行，然后环化，依次形成CN和CS键。该工艺在各种芳基甲基酮中表现出平滑的反应性，以良好的收率生产所需的产品。该方法还可以很容易地扩大到克级，收率可达68%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

NH4I/TBHP-mediated synthesis of 2-aroylbenzothiazoles through [4 + 1] oxidative annulation of 2-aminothiophenols and aryl methyl ketones

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NH4I/TBHP-mediated synthesis of 2-aroylbenzothiazoles through [4 + 1] oxidative annulation of 2-aminothiophenols and aryl methyl ketones

An efficient one-pot protocol has been established for the synthesis of 2-aroylbenzothiazoles by using the combination of NH₄I/TBHP system. The reaction proceeds through NH₄I/TBHP-mediated oxidation of aryl methyl ketones followed by annulation with sequential CN and CS bond formation. The process demonstrates smooth reactivity across a diverse range of aryl methyl ketones, producing the desired products in good to excellent yields. This method can also be easily scaled up to gram level, resulting in yield of up to 68 %.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.