角膜移位性结膜黑色素瘤：复发性黑色素瘤的罕见表现

Q3 Medicine

American Journal of Ophthalmology Case Reports Pub Date : 2025-07-15 DOI:10.1016/j.ajoc.2025.102387

Eric Boya Lee , Ahmad Al-Moujahed , Michael D. Yu , Christopher N. Ta , Jonathan H. Lin , Prithvi Mruthyunjaya

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引用次数: 0

摘要

目的对2例多次复发的角膜移位性结膜黑色素瘤进行长期随访。病例1是一名49岁男性，患有复发性结膜黑色素瘤和原发性获得性黑色素病，治疗超过13年，最终表现为无色素性角膜肿块升高。病例2是一名61岁的女性，有相似的复发性结膜黑色素瘤和原发性获得性黑色素病的病史，治疗超过21年，表现为角膜上皮下混浊。两例患者均接受了局部化疗、广泛切除、穿刺活检、冷冻治疗以及局部和全身检查，均未发现转移迹象。结论和重要性结膜黑色素瘤复发风险高，可表现为无色素变性角膜移位结膜黑色素瘤，需要彻底检查以发现该疾病潜在的亚临床传播。

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Corneally displaced conjunctival Melanoma: Rare presentations of recurrent melanoma

Purpose

To describe long term follow-up of two cases of corneally displaced conjunctival melanoma with multiple recurrences.

Observations

Case 1 is a 49-year-old male with recurrent conjunctival melanoma and primary acquired melanosis treated over 13 years, who eventually presented with an elevated amelanotic corneal mass. Case 2 is a 61-year-old female with a similar history of recurrent conjunctival melanoma and primary acquired melanosis treated over 21 years, who presented with a subepithelial corneal opacity. Both patients were treated with a combination of topical chemotherapy, wide excision, map biopsy, cryotherapy, and local and systemic workup showing no evidence of metastasis.

Conclusions and importance

Conjunctival melanoma has a high risk of recurrence and can present as amelanotic corneally displaced conjunctival melanoma, warranting thorough workup to detect potential subclinical spread of the disease.

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来源期刊

American Journal of Ophthalmology Case Reports Medicine-Ophthalmology

CiteScore

2.40

自引率

0.00%

发文量

513

审稿时长

16 weeks

期刊介绍： The American Journal of Ophthalmology Case Reports is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished case report manuscripts directed to ophthalmologists and visual science specialists. The cases shall be challenging and stimulating but shall also be presented in an educational format to engage the readers as if they are working alongside with the caring clinician scientists to manage the patients. Submissions shall be clear, concise, and well-documented reports. Brief reports and case series submissions on specific themes are also very welcome.