生物医学工程中刺激响应聚合物的3D/4D打印：材料，刺激和应用

IF 31.6 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Science and Engineering: R: Reports Pub Date : 2025-07-23 DOI:10.1016/j.mser.2025.101071

Wenzheng Wu , Jiaqing Wang , Guiwei Li

{"title":"生物医学工程中刺激响应聚合物的3D/4D打印：材料，刺激和应用","authors":"Wenzheng Wu , Jiaqing Wang , Guiwei Li","doi":"10.1016/j.mser.2025.101071","DOIUrl":null,"url":null,"abstract":"<div><div>Four-dimensional (4D) printing integrates smart materials with three-dimensional (3D) printing to create structures that undergo programmable shape or property changes. These transformations are triggered by external stimuli including humidity, light, heat, electric fields, or magnetic fields. Leveraging adaptability, self-regulation, and self-deformation capabilities, this technology shows transformative potential in biomedical engineering applications such as tissue engineering, implantable devices, drug delivery systems, and precision medical instruments. This review systematically examines 4D printing's role in biomedical innovation, focusing on material selection, stimulus-response mechanisms, and emerging applications. Following an overview of 4D printing's foundational concepts and principles, the analysis delves into stimulus-responsive polymers in biomedical contexts. The transformative potential of shape-morphing polymers is explored across smart implants, adaptive medical devices, controlled drug release platforms, biofabricated organs, and minimally invasive surgical solutions. Current trends and future trajectories in biomedical 3D/4D printing are critically evaluated, highlighting technical challenges, material innovation opportunities, and translational pathways for clinical implementation in this dynamic interdisciplinary field.</div></div>","PeriodicalId":386,"journal":{"name":"Materials Science and Engineering: R: Reports","volume":"166 ","pages":"Article 101071"},"PeriodicalIF":31.6000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"3D/4D printing of stimuli-responsive polymers in biomedical engineering: Materials, stimulations, and applications\",\"authors\":\"Wenzheng Wu , Jiaqing Wang , Guiwei Li\",\"doi\":\"10.1016/j.mser.2025.101071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Four-dimensional (4D) printing integrates smart materials with three-dimensional (3D) printing to create structures that undergo programmable shape or property changes. These transformations are triggered by external stimuli including humidity, light, heat, electric fields, or magnetic fields. Leveraging adaptability, self-regulation, and self-deformation capabilities, this technology shows transformative potential in biomedical engineering applications such as tissue engineering, implantable devices, drug delivery systems, and precision medical instruments. This review systematically examines 4D printing's role in biomedical innovation, focusing on material selection, stimulus-response mechanisms, and emerging applications. Following an overview of 4D printing's foundational concepts and principles, the analysis delves into stimulus-responsive polymers in biomedical contexts. The transformative potential of shape-morphing polymers is explored across smart implants, adaptive medical devices, controlled drug release platforms, biofabricated organs, and minimally invasive surgical solutions. Current trends and future trajectories in biomedical 3D/4D printing are critically evaluated, highlighting technical challenges, material innovation opportunities, and translational pathways for clinical implementation in this dynamic interdisciplinary field.</div></div>\",\"PeriodicalId\":386,\"journal\":{\"name\":\"Materials Science and Engineering: R: Reports\",\"volume\":\"166 \",\"pages\":\"Article 101071\"},\"PeriodicalIF\":31.6000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Science and Engineering: R: Reports\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927796X25001494\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Science and Engineering: R: Reports","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927796X25001494","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

四维（4D）打印将智能材料与三维（3D）打印相结合，以创建可编程形状或属性变化的结构。这些转变是由外部刺激触发的，包括湿度、光、热、电场或磁场。利用适应性、自我调节和自我变形能力，这项技术在生物医学工程应用中显示出革命性的潜力，如组织工程、植入式设备、药物输送系统和精密医疗仪器。本文系统地探讨了4D打印在生物医学创新中的作用，重点是材料选择，刺激-反应机制和新兴应用。以下4D打印的基本概念和原理的概述，分析深入到生物医学环境中的刺激反应聚合物。在智能植入物、自适应医疗设备、受控药物释放平台、生物制造器官和微创手术解决方案中，探索了形状变形聚合物的变革潜力。对生物医学3D/4D打印的当前趋势和未来轨迹进行了批判性评估，突出了技术挑战、材料创新机会以及在这个充满活力的跨学科领域中临床实施的转化途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

3D/4D printing of stimuli-responsive polymers in biomedical engineering: Materials, stimulations, and applications

Four-dimensional (4D) printing integrates smart materials with three-dimensional (3D) printing to create structures that undergo programmable shape or property changes. These transformations are triggered by external stimuli including humidity, light, heat, electric fields, or magnetic fields. Leveraging adaptability, self-regulation, and self-deformation capabilities, this technology shows transformative potential in biomedical engineering applications such as tissue engineering, implantable devices, drug delivery systems, and precision medical instruments. This review systematically examines 4D printing's role in biomedical innovation, focusing on material selection, stimulus-response mechanisms, and emerging applications. Following an overview of 4D printing's foundational concepts and principles, the analysis delves into stimulus-responsive polymers in biomedical contexts. The transformative potential of shape-morphing polymers is explored across smart implants, adaptive medical devices, controlled drug release platforms, biofabricated organs, and minimally invasive surgical solutions. Current trends and future trajectories in biomedical 3D/4D printing are critically evaluated, highlighting technical challenges, material innovation opportunities, and translational pathways for clinical implementation in this dynamic interdisciplinary field.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Materials Science and Engineering: R: Reports 工程技术-材料科学：综合

CiteScore

60.50

自引率

0.30%

发文量

审稿时长

34 days

期刊介绍： Materials Science & Engineering R: Reports is a journal that covers a wide range of topics in the field of materials science and engineering. It publishes both experimental and theoretical research papers, providing background information and critical assessments on various topics. The journal aims to publish high-quality and novel research papers and reviews. The subject areas covered by the journal include Materials Science (General), Electronic Materials, Optical Materials, and Magnetic Materials. In addition to regular issues, the journal also publishes special issues on key themes in the field of materials science, including Energy Materials, Materials for Health, Materials Discovery, Innovation for High Value Manufacturing, and Sustainable Materials development.