{"title":"纳武单抗诱导的免疫治疗相关性膀胱炎：1例报告和文献回顾","authors":"Yingying Yuan , Lianqing Lou , Siheng Zhu , Dong Yan","doi":"10.1016/j.eucr.2025.103132","DOIUrl":null,"url":null,"abstract":"<div><div>Immune checkpoint inhibitors (ICIs) like nivolumab have revolutionized cancer treatment but can cause immune-related adverse events (irAEs), including rare cystitis. This case report describes a gastric cancer patient who developed urinary symptoms, such as hematuria and frequent urination, after nivolumab treatment. Despite initial antibiotics, symptoms worsened, leading to a diagnosis of immune-related cystitis. Intravenous methylprednisolone provided rapid relief and restored renal function. Early recognition and corticosteroid treatment are crucial for managing ICI-induced cystitis and preventing unnecessary antibiotics.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103132"},"PeriodicalIF":0.4000,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunotherapy-related cystitis induced by nivolumab: A case report and review of the literature\",\"authors\":\"Yingying Yuan , Lianqing Lou , Siheng Zhu , Dong Yan\",\"doi\":\"10.1016/j.eucr.2025.103132\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Immune checkpoint inhibitors (ICIs) like nivolumab have revolutionized cancer treatment but can cause immune-related adverse events (irAEs), including rare cystitis. This case report describes a gastric cancer patient who developed urinary symptoms, such as hematuria and frequent urination, after nivolumab treatment. Despite initial antibiotics, symptoms worsened, leading to a diagnosis of immune-related cystitis. Intravenous methylprednisolone provided rapid relief and restored renal function. Early recognition and corticosteroid treatment are crucial for managing ICI-induced cystitis and preventing unnecessary antibiotics.</div></div>\",\"PeriodicalId\":38188,\"journal\":{\"name\":\"Urology Case Reports\",\"volume\":\"62 \",\"pages\":\"Article 103132\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2025-07-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2214442025002037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2214442025002037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Immunotherapy-related cystitis induced by nivolumab: A case report and review of the literature
Immune checkpoint inhibitors (ICIs) like nivolumab have revolutionized cancer treatment but can cause immune-related adverse events (irAEs), including rare cystitis. This case report describes a gastric cancer patient who developed urinary symptoms, such as hematuria and frequent urination, after nivolumab treatment. Despite initial antibiotics, symptoms worsened, leading to a diagnosis of immune-related cystitis. Intravenous methylprednisolone provided rapid relief and restored renal function. Early recognition and corticosteroid treatment are crucial for managing ICI-induced cystitis and preventing unnecessary antibiotics.
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