Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in pediatrics.

Introduction: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has a low malignancy potential. First acknowledged by the WHO in 2017, this tumor is rare in the pediatric population, with less than 25 cases reported. Accurate diagnosis is key to avoid overtreatment and complications.

Clinical observation: Two cases of adolescents with solid thyroid nodules assessed by fine-needle aspiration biopsy are presented. Hemithyroidectomy was decided upon. Both surgical specimens were reported as NIFTP. Both cases were presented before a cross-disciplinary board, and since malignancy potential was low, treatment was regarded as completed.

Discussion: NIFTP identification is key to avoid unnecessary treatments such as total thyroidectomy or iodine therapy, which may bring about serious consequences in children. A high level of diagnostic suspicion and a cross-disciplinary approach are required to optimize management and clinical results in these patients.