{"title":"肺神经内分泌肿瘤手术切除后的长期生存预后。","authors":"Eisuke Goto, Keiju Aokage, Kotaro Nomura, Makoto Tada, Yutaro Koike, Tetsuro Taki, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Kenji Suzuki, Genichiro Ishii, Masahiro Tsuboi","doi":"10.1007/s00595-025-03077-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Surgery is the standard treatment for early-stage pulmonary neuroendocrine tumors (NETs); however, long-term prognostic data are limited. This study aimed to establish the long-term outcomes of surgically resected pulmonary NETs.</p><p><strong>Methods: </strong>This study included 263 patients who underwent pulmonary resection between January, 1997 and December, 2019: 89 with small cell lung carcinoma (SCLC), 120 with large cell neuroendocrine carcinoma (LCNEC), 14 with atypical carcinoid (AC), and 40 with typical carcinoid (TC). We analyzed clinicopathological characteristics and long-term prognosis.</p><p><strong>Results: </strong>The 5-year relapse-free survival (RFS) rates were 38.7%, 54.2%, 62.3%, and 85.0%, and the 10-year RFS rates were 24.5%, 39.8%, 20.8%, and 76.4% for SCLC, LCNEC, AC, and TC, respectively. All deaths from TC occurred more than 5 years after surgery, whereas three of the four deaths from AC occurred after this period. Most patients with high-grade NETs had relapses within 3 years after surgery, whereas patients with AC had relapses not only in the early phase but also in the late phase.</p><p><strong>Conclusions: </strong>The long-term prognosis of AC is comparable to that of high-grade NETs, suggesting that its biological characteristics might be more closely related to high-grade NETs than to TC.</p>","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term survival outcome after surgical resection of pulmonary neuroendocrine tumors.\",\"authors\":\"Eisuke Goto, Keiju Aokage, Kotaro Nomura, Makoto Tada, Yutaro Koike, Tetsuro Taki, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Kenji Suzuki, Genichiro Ishii, Masahiro Tsuboi\",\"doi\":\"10.1007/s00595-025-03077-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Surgery is the standard treatment for early-stage pulmonary neuroendocrine tumors (NETs); however, long-term prognostic data are limited. This study aimed to establish the long-term outcomes of surgically resected pulmonary NETs.</p><p><strong>Methods: </strong>This study included 263 patients who underwent pulmonary resection between January, 1997 and December, 2019: 89 with small cell lung carcinoma (SCLC), 120 with large cell neuroendocrine carcinoma (LCNEC), 14 with atypical carcinoid (AC), and 40 with typical carcinoid (TC). We analyzed clinicopathological characteristics and long-term prognosis.</p><p><strong>Results: </strong>The 5-year relapse-free survival (RFS) rates were 38.7%, 54.2%, 62.3%, and 85.0%, and the 10-year RFS rates were 24.5%, 39.8%, 20.8%, and 76.4% for SCLC, LCNEC, AC, and TC, respectively. All deaths from TC occurred more than 5 years after surgery, whereas three of the four deaths from AC occurred after this period. Most patients with high-grade NETs had relapses within 3 years after surgery, whereas patients with AC had relapses not only in the early phase but also in the late phase.</p><p><strong>Conclusions: </strong>The long-term prognosis of AC is comparable to that of high-grade NETs, suggesting that its biological characteristics might be more closely related to high-grade NETs than to TC.</p>\",\"PeriodicalId\":22163,\"journal\":{\"name\":\"Surgery Today\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surgery Today\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00595-025-03077-z\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgery Today","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00595-025-03077-z","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
Long-term survival outcome after surgical resection of pulmonary neuroendocrine tumors.
Purpose: Surgery is the standard treatment for early-stage pulmonary neuroendocrine tumors (NETs); however, long-term prognostic data are limited. This study aimed to establish the long-term outcomes of surgically resected pulmonary NETs.
Methods: This study included 263 patients who underwent pulmonary resection between January, 1997 and December, 2019: 89 with small cell lung carcinoma (SCLC), 120 with large cell neuroendocrine carcinoma (LCNEC), 14 with atypical carcinoid (AC), and 40 with typical carcinoid (TC). We analyzed clinicopathological characteristics and long-term prognosis.
Results: The 5-year relapse-free survival (RFS) rates were 38.7%, 54.2%, 62.3%, and 85.0%, and the 10-year RFS rates were 24.5%, 39.8%, 20.8%, and 76.4% for SCLC, LCNEC, AC, and TC, respectively. All deaths from TC occurred more than 5 years after surgery, whereas three of the four deaths from AC occurred after this period. Most patients with high-grade NETs had relapses within 3 years after surgery, whereas patients with AC had relapses not only in the early phase but also in the late phase.
Conclusions: The long-term prognosis of AC is comparable to that of high-grade NETs, suggesting that its biological characteristics might be more closely related to high-grade NETs than to TC.
期刊介绍:
Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it").
The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.