{"title":"单次400hz经颅脉冲电流刺激对皮质脊髓和皮质皮质兴奋性及手灵巧性的影响：一项双盲随机对照试验。","authors":"Shapour Jaberzadeh, Mona Malekahmad, Renming Liu, Maryam Zoghi","doi":"10.1111/psyp.70112","DOIUrl":null,"url":null,"abstract":"<p><p>The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a-tPCS<sub>M1</sub>, 400 Hz c-tPCS<sub>M1</sub>) on corticospinal excitability (CSE) and corticocortical excitability (CCE) and hand dexterity remain underexplored. This study examined the effects of a single session of 400 Hz a-tPCS<sub>M1</sub>, 400 Hz c-tPCS<sub>M1</sub>, and sham stimulation on CSE, CCE, and hand dexterity, providing insights for potential clinical applications in motor deficits. In this double-blinded, randomized, counterbalanced crossover trial, 26 healthy young adults completed three experimental sessions: 400 Hz a-tPCS<sub>M1</sub>, 400 Hz c-tPCS<sub>M1</sub>, and sham stimulation, spaced 48 h apart. Transcranial magnetic stimulation assessed CSE and CCE, while the Purdue Pegboard Test (PPT) evaluated hand dexterity. The results showed polarity-specific effects. A single session of 400 Hz a-tPCS<sub>M1</sub> significantly increased CSE and improved hand dexterity, evidenced by faster PPT completion times (p < 0.05). Conversely, 400 Hz c-tPCS<sub>M1</sub> reduced CSE but did not influence PPT performance (p > 0.05). Sham stimulation showed no significant changes. These findings suggest that 400 Hz a-tPCS<sub>M1</sub> enhances motor excitability and dexterity, while 400 Hz c-tPCS<sub>M1</sub> selectively reduces CSE. This study lays a foundation for exploring high-frequency tPCS in clinical motor rehabilitation.</p>","PeriodicalId":20913,"journal":{"name":"Psychophysiology","volume":"62 7","pages":"e70112"},"PeriodicalIF":2.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284344/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effects of a Single Session 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT.\",\"authors\":\"Shapour Jaberzadeh, Mona Malekahmad, Renming Liu, Maryam Zoghi\",\"doi\":\"10.1111/psyp.70112\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a-tPCS<sub>M1</sub>, 400 Hz c-tPCS<sub>M1</sub>) on corticospinal excitability (CSE) and corticocortical excitability (CCE) and hand dexterity remain underexplored. This study examined the effects of a single session of 400 Hz a-tPCS<sub>M1</sub>, 400 Hz c-tPCS<sub>M1</sub>, and sham stimulation on CSE, CCE, and hand dexterity, providing insights for potential clinical applications in motor deficits. In this double-blinded, randomized, counterbalanced crossover trial, 26 healthy young adults completed three experimental sessions: 400 Hz a-tPCS<sub>M1</sub>, 400 Hz c-tPCS<sub>M1</sub>, and sham stimulation, spaced 48 h apart. Transcranial magnetic stimulation assessed CSE and CCE, while the Purdue Pegboard Test (PPT) evaluated hand dexterity. The results showed polarity-specific effects. A single session of 400 Hz a-tPCS<sub>M1</sub> significantly increased CSE and improved hand dexterity, evidenced by faster PPT completion times (p < 0.05). Conversely, 400 Hz c-tPCS<sub>M1</sub> reduced CSE but did not influence PPT performance (p > 0.05). Sham stimulation showed no significant changes. These findings suggest that 400 Hz a-tPCS<sub>M1</sub> enhances motor excitability and dexterity, while 400 Hz c-tPCS<sub>M1</sub> selectively reduces CSE. This study lays a foundation for exploring high-frequency tPCS in clinical motor rehabilitation.</p>\",\"PeriodicalId\":20913,\"journal\":{\"name\":\"Psychophysiology\",\"volume\":\"62 7\",\"pages\":\"e70112\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284344/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychophysiology\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1111/psyp.70112\",\"RegionNum\":2,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychophysiology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1111/psyp.70112","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Effects of a Single Session 400 Hz Transcranial Pulsed Current Stimulation on Corticospinal and Corticocortical Excitability and Hand Dexterity: A Double-Blind RCT.
The effects of 400 Hz anodal and cathodal transcranial pulsed current stimulation of the primary motor cortex (400 Hz a-tPCSM1, 400 Hz c-tPCSM1) on corticospinal excitability (CSE) and corticocortical excitability (CCE) and hand dexterity remain underexplored. This study examined the effects of a single session of 400 Hz a-tPCSM1, 400 Hz c-tPCSM1, and sham stimulation on CSE, CCE, and hand dexterity, providing insights for potential clinical applications in motor deficits. In this double-blinded, randomized, counterbalanced crossover trial, 26 healthy young adults completed three experimental sessions: 400 Hz a-tPCSM1, 400 Hz c-tPCSM1, and sham stimulation, spaced 48 h apart. Transcranial magnetic stimulation assessed CSE and CCE, while the Purdue Pegboard Test (PPT) evaluated hand dexterity. The results showed polarity-specific effects. A single session of 400 Hz a-tPCSM1 significantly increased CSE and improved hand dexterity, evidenced by faster PPT completion times (p < 0.05). Conversely, 400 Hz c-tPCSM1 reduced CSE but did not influence PPT performance (p > 0.05). Sham stimulation showed no significant changes. These findings suggest that 400 Hz a-tPCSM1 enhances motor excitability and dexterity, while 400 Hz c-tPCSM1 selectively reduces CSE. This study lays a foundation for exploring high-frequency tPCS in clinical motor rehabilitation.
期刊介绍：
Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.
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