Xu Zhou, Shenghua Qin, Chunhai Huang, Feiwen Li, Jin Liu, Ti Wu, Mingzheng Zhang
{"title":"经皮椎体成形术联合经皮椎体成形术的生物力学评价:有限元分析。","authors":"Xu Zhou, Shenghua Qin, Chunhai Huang, Feiwen Li, Jin Liu, Ti Wu, Mingzheng Zhang","doi":"10.3389/fbioe.2025.1606709","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Since the introduction of percutaneous cement discoplasty (PCD), numerous studies have confirmed its clinical efficacy in elderly patients. However, PCD is also associated with risks such as bone cement leakage and vertebral fractures. The purpose of this study was to present a biomechanical evaluation of two modified versions of PCD performed in combination with percutaneous vertebroplasty (PVP).</p><p><strong>Methods: </strong>Data from a CT scan of a healthy male's lumbosacral region were used to establish finite element (FE) models of nonsurgical treatment, PCD, L4/5PCD + L4L5PVP (modified technique 1, where the bone cement in the L4/5 disc space does not connect with the L4 and L5 vertebrae) and PCIF (modified technique 2, where the bone cement in the L4/5 disc space connects with the L4 and L5 vertebrae). A compressive of preload 150 N and a moment of 10 N·m were applied to recreate flexion, extension, lateral bending, and axial rotation. The range of motion (ROM) of L3/4 and L4/5, maximum stress on the L3 inferior endplate, L4 inferior endplate and L5 superior endplate, stress on the annulus fibrosus of L4/5, and displacement of the bone cement were evaluated.</p><p><strong>Results: </strong>Both modified techniques outperformed the simple PCD technique in reducing stress on the endplate, stress on the annulus fibrosus, and displacement of the bone cement. The L4/5PCD + L4L5PVP technique was more advantageous in terms of reducing the incidence of postoperative complications. The addition of the PVP technique significantly enhanced spinal stability by increasing support to adjacent vertebrae, thereby reducing the risk of postoperative endplate fractures and bone cement leakage.</p><p><strong>Conclusion: </strong>Modified PCD combined with PVP may be a safer and more effective option for treating degenerative disc diseases, providing important references for clinical treatment.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1606709"},"PeriodicalIF":4.3000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279793/pdf/","citationCount":"0","resultStr":"{\"title\":\"Biomechanical evaluation of percutaneous cement discoplasty combined with percutaneous vertebroplasty: a finite element analysis.\",\"authors\":\"Xu Zhou, Shenghua Qin, Chunhai Huang, Feiwen Li, Jin Liu, Ti Wu, Mingzheng Zhang\",\"doi\":\"10.3389/fbioe.2025.1606709\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Since the introduction of percutaneous cement discoplasty (PCD), numerous studies have confirmed its clinical efficacy in elderly patients. However, PCD is also associated with risks such as bone cement leakage and vertebral fractures. The purpose of this study was to present a biomechanical evaluation of two modified versions of PCD performed in combination with percutaneous vertebroplasty (PVP).</p><p><strong>Methods: </strong>Data from a CT scan of a healthy male's lumbosacral region were used to establish finite element (FE) models of nonsurgical treatment, PCD, L4/5PCD + L4L5PVP (modified technique 1, where the bone cement in the L4/5 disc space does not connect with the L4 and L5 vertebrae) and PCIF (modified technique 2, where the bone cement in the L4/5 disc space connects with the L4 and L5 vertebrae). A compressive of preload 150 N and a moment of 10 N·m were applied to recreate flexion, extension, lateral bending, and axial rotation. The range of motion (ROM) of L3/4 and L4/5, maximum stress on the L3 inferior endplate, L4 inferior endplate and L5 superior endplate, stress on the annulus fibrosus of L4/5, and displacement of the bone cement were evaluated.</p><p><strong>Results: </strong>Both modified techniques outperformed the simple PCD technique in reducing stress on the endplate, stress on the annulus fibrosus, and displacement of the bone cement. The L4/5PCD + L4L5PVP technique was more advantageous in terms of reducing the incidence of postoperative complications. The addition of the PVP technique significantly enhanced spinal stability by increasing support to adjacent vertebrae, thereby reducing the risk of postoperative endplate fractures and bone cement leakage.</p><p><strong>Conclusion: </strong>Modified PCD combined with PVP may be a safer and more effective option for treating degenerative disc diseases, providing important references for clinical treatment.</p>\",\"PeriodicalId\":12444,\"journal\":{\"name\":\"Frontiers in Bioengineering and Biotechnology\",\"volume\":\"13 \",\"pages\":\"1606709\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279793/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Bioengineering and Biotechnology\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.3389/fbioe.2025.1606709\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1606709","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
Biomechanical evaluation of percutaneous cement discoplasty combined with percutaneous vertebroplasty: a finite element analysis.
Introduction: Since the introduction of percutaneous cement discoplasty (PCD), numerous studies have confirmed its clinical efficacy in elderly patients. However, PCD is also associated with risks such as bone cement leakage and vertebral fractures. The purpose of this study was to present a biomechanical evaluation of two modified versions of PCD performed in combination with percutaneous vertebroplasty (PVP).
Methods: Data from a CT scan of a healthy male's lumbosacral region were used to establish finite element (FE) models of nonsurgical treatment, PCD, L4/5PCD + L4L5PVP (modified technique 1, where the bone cement in the L4/5 disc space does not connect with the L4 and L5 vertebrae) and PCIF (modified technique 2, where the bone cement in the L4/5 disc space connects with the L4 and L5 vertebrae). A compressive of preload 150 N and a moment of 10 N·m were applied to recreate flexion, extension, lateral bending, and axial rotation. The range of motion (ROM) of L3/4 and L4/5, maximum stress on the L3 inferior endplate, L4 inferior endplate and L5 superior endplate, stress on the annulus fibrosus of L4/5, and displacement of the bone cement were evaluated.
Results: Both modified techniques outperformed the simple PCD technique in reducing stress on the endplate, stress on the annulus fibrosus, and displacement of the bone cement. The L4/5PCD + L4L5PVP technique was more advantageous in terms of reducing the incidence of postoperative complications. The addition of the PVP technique significantly enhanced spinal stability by increasing support to adjacent vertebrae, thereby reducing the risk of postoperative endplate fractures and bone cement leakage.
Conclusion: Modified PCD combined with PVP may be a safer and more effective option for treating degenerative disc diseases, providing important references for clinical treatment.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.