Carboxamide:开发抗感染和抗癌药物的优势药效团。

IF 3.3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Xiaopei Yang, Zirui Jiao, Kasemsiri Chandarajoti, Sai Lv, Xisong Ke, Wen Zhou
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引用次数: 0

摘要

Carboxamide是一种特殊的支架,经常用于fda批准的药物。与传统酰胺表现出类似价键的性质不同,carboxamide具有更优异的结合模式,从而构建了丰富的药理活性。根据其特定结构的不同工作原理和n端取代,又可分为n -未取代的carboxamide和n -取代的carboxamide。这两种羧胺在药物设计和开发中得到了广泛的研究和应用。本文从结合方式入手,综述了羧基酰胺的优良结构、目前的研究进展以及在抗感染和抗癌领域面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Carboxamide: A Privileged Pharmacophore for the Development of Anti-infectious and Anti-cancer Drugs.

Carboxamide is a privileged scaffold that is often used in FDA-approved drugs. Unlike traditional amides, which exhibit properties similar to valence bonds, carboxamide has a more excellent binding mode and thus constructs rich pharmacological activities. According to the different working principles and N-terminus substitution of its specific structures, carboxamide can be further divided into N-unsubstituted carboxamide and N-substituted carboxamide. Both kinds of carboxamides have been widely studied and used in drug design and development. This review starts from the binding style and thus summarizes the excellent carboxamide structures, current research progress, and future challenges in the fields of anti-infection and anti-cancer.

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来源期刊
CiteScore
6.40
自引率
2.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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