缰状星形胶质细胞中的钙动态调节行为转变中的主动应对。

IF 5.2 1区生物学 Q1 BIOLOGY

Communications Biology Pub Date : 2025-07-22 DOI:10.1038/s42003-025-08535-5

Léo Michel, Denys Osypenko, Patricia Molina, Kadir A Mutlu, Salvatore Lecca, Chihiro Hisatsune, Katsuhiko Mikoshiba, Toko Kikuchi, Emre Yaksi, Andrea Volterra, Manuel Mameli

{"title":"缰状星形胶质细胞中的钙动态调节行为转变中的主动应对。","authors":"Léo Michel, Denys Osypenko, Patricia Molina, Kadir A Mutlu, Salvatore Lecca, Chihiro Hisatsune, Katsuhiko Mikoshiba, Toko Kikuchi, Emre Yaksi, Andrea Volterra, Manuel Mameli","doi":"10.1038/s42003-025-08535-5","DOIUrl":null,"url":null,"abstract":"Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.","PeriodicalId":10552,"journal":{"name":"Communications Biology","volume":"8 1","pages":"1087"},"PeriodicalIF":5.2000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions.\",\"authors\":\"Léo Michel, Denys Osypenko, Patricia Molina, Kadir A Mutlu, Salvatore Lecca, Chihiro Hisatsune, Katsuhiko Mikoshiba, Toko Kikuchi, Emre Yaksi, Andrea Volterra, Manuel Mameli\",\"doi\":\"10.1038/s42003-025-08535-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.\",\"PeriodicalId\":10552,\"journal\":{\"name\":\"Communications Biology\",\"volume\":\"8 1\",\"pages\":\"1087\"},\"PeriodicalIF\":5.2000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Communications Biology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s42003-025-08535-5\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Communications Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s42003-025-08535-5","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

行为上的挑战促使人们交替地积极应对和减少流动性——主动应对和被动应对——从而优化能量投资。在这里，我们发现破坏小鼠侧链（LHb）中的星形胶质细胞钙信号延长了主动应对。这种状态通过小鼠和斑马鱼缰状星形胶质细胞的钙升高表现出来。突触前追踪方法将LHb星形胶质细胞整合到厌恶相关的神经回路中。因此，星形胶质细胞调节状态转换，突出了它们对跨物种行为的计算贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions.

Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Communications Biology Medicine-Medicine (miscellaneous)

CiteScore

8.60

自引率

1.70%

发文量

1233

审稿时长

13 weeks

期刊介绍： Communications Biology is an open access journal from Nature Research publishing high-quality research, reviews and commentary in all areas of the biological sciences. Research papers published by the journal represent significant advances bringing new biological insight to a specialized area of research.