重复I型波士顿角膜假体的远期预后。

IF 2.8 4区 医学 Q1 OPHTHALMOLOGY
Wissam B Nassrallah, Emma Youhnovska, Mai Katbe, Andre Pollmann, Fady Sedarous, Rayan Tolba, Dominique Geoffrion, Mona Harissi-Dagher
{"title":"重复I型波士顿角膜假体的远期预后。","authors":"Wissam B Nassrallah, Emma Youhnovska, Mai Katbe, Andre Pollmann, Fady Sedarous, Rayan Tolba, Dominique Geoffrion, Mona Harissi-Dagher","doi":"10.1016/j.jcjo.2025.06.027","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The Boston Type I keratoprosthesis (B-KPro) is a synthetic corneal implant used to restore vision in cases of corneal blindness. While the B-KPro can achieve a visual acuity of better than 20/200, it is associated with a risk of implant failure. In cases of failure, a repeat B-KPro may offer another opportunity for vision restoration. This study aims to evaluate the long-term outcomes of patients undergoing repeat B-KPro after failure of the initial implant.</p><p><strong>Design: </strong>This is a retrospective cohort study.</p><p><strong>Participants: </strong>Eighteen patients who underwent two B-KPro implantations in the same eye, with a mean follow-up period of 8.1 ± 4.6 years.</p><p><strong>Methods: </strong>The primary endpoints were the failure rate of the implant and visual acuity at the last follow-up.</p><p><strong>Results: </strong>The failure rate of the repeat B-KPro (11.11% at 5 years) was significantly lower than that of the first B-KPro (88.89% at 5 years) (p < 0.0001) for the repeat cohort. Visual acuity better than 20/200 was achieved in 30.09% and 24.07% of patients at 3 years and 6 years, respectively, following repeat B-KPro, similar to outcomes observed after the first B-KPro. The incidence of phthisis was higher after the repeat B-KPro, but the rates of hypotony, endophthalmitis, corneal melt, and extrusion were lower compared to the first B-KPro.</p><p><strong>Conclusions: </strong>Repeat B-KPro can provide sustained visual acuity better than 20/200 after failure of the initial implant. Further studies with larger cohorts are needed to better understand the risks and benefits associated with repeat B-KPro.</p>","PeriodicalId":9606,"journal":{"name":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Long-term prognosis of repeat Type I Boston keratoprosthesis.\",\"authors\":\"Wissam B Nassrallah, Emma Youhnovska, Mai Katbe, Andre Pollmann, Fady Sedarous, Rayan Tolba, Dominique Geoffrion, Mona Harissi-Dagher\",\"doi\":\"10.1016/j.jcjo.2025.06.027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The Boston Type I keratoprosthesis (B-KPro) is a synthetic corneal implant used to restore vision in cases of corneal blindness. While the B-KPro can achieve a visual acuity of better than 20/200, it is associated with a risk of implant failure. In cases of failure, a repeat B-KPro may offer another opportunity for vision restoration. This study aims to evaluate the long-term outcomes of patients undergoing repeat B-KPro after failure of the initial implant.</p><p><strong>Design: </strong>This is a retrospective cohort study.</p><p><strong>Participants: </strong>Eighteen patients who underwent two B-KPro implantations in the same eye, with a mean follow-up period of 8.1 ± 4.6 years.</p><p><strong>Methods: </strong>The primary endpoints were the failure rate of the implant and visual acuity at the last follow-up.</p><p><strong>Results: </strong>The failure rate of the repeat B-KPro (11.11% at 5 years) was significantly lower than that of the first B-KPro (88.89% at 5 years) (p < 0.0001) for the repeat cohort. Visual acuity better than 20/200 was achieved in 30.09% and 24.07% of patients at 3 years and 6 years, respectively, following repeat B-KPro, similar to outcomes observed after the first B-KPro. The incidence of phthisis was higher after the repeat B-KPro, but the rates of hypotony, endophthalmitis, corneal melt, and extrusion were lower compared to the first B-KPro.</p><p><strong>Conclusions: </strong>Repeat B-KPro can provide sustained visual acuity better than 20/200 after failure of the initial implant. Further studies with larger cohorts are needed to better understand the risks and benefits associated with repeat B-KPro.</p>\",\"PeriodicalId\":9606,\"journal\":{\"name\":\"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-08-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jcjo.2025.06.027\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of ophthalmology. Journal canadien d'ophtalmologie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jcjo.2025.06.027","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:波士顿I型角膜假体(B-KPro)是一种用于角膜失明患者恢复视力的人工角膜植入物。虽然B-KPro可以达到20/200以上的视力,但它有植入失败的风险。在失败的情况下,重复B-KPro可能提供另一个恢复视力的机会。本研究旨在评估首次植入失败后再次接受B-KPro的患者的长期预后。设计:这是一项回顾性队列研究。参与者:18例患者在同一只眼睛内接受了两次B-KPro植入,平均随访时间为8.1±4.6年。方法:最后一次随访时,以植体失败率和视力为主要观察终点。结果:在重复队列中,重复B-KPro的失败率(5年11.11%)显著低于第一次B-KPro的失败率(5年88.89%)(p < 0.0001)。重复B-KPro后3年和6年,分别有30.09%和24.07%的患者视力优于20/200,与第一次B-KPro后观察到的结果相似。与第一次B-KPro相比,重复B-KPro后肺结核的发生率较高,但低斜视、眼内炎、角膜融化和挤压的发生率较低。结论:B-KPro可在初次植入失败后提供20/200以上的持续视力。需要更大规模的进一步研究来更好地了解重复B-KPro的风险和益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long-term prognosis of repeat Type I Boston keratoprosthesis.

Objective: The Boston Type I keratoprosthesis (B-KPro) is a synthetic corneal implant used to restore vision in cases of corneal blindness. While the B-KPro can achieve a visual acuity of better than 20/200, it is associated with a risk of implant failure. In cases of failure, a repeat B-KPro may offer another opportunity for vision restoration. This study aims to evaluate the long-term outcomes of patients undergoing repeat B-KPro after failure of the initial implant.

Design: This is a retrospective cohort study.

Participants: Eighteen patients who underwent two B-KPro implantations in the same eye, with a mean follow-up period of 8.1 ± 4.6 years.

Methods: The primary endpoints were the failure rate of the implant and visual acuity at the last follow-up.

Results: The failure rate of the repeat B-KPro (11.11% at 5 years) was significantly lower than that of the first B-KPro (88.89% at 5 years) (p < 0.0001) for the repeat cohort. Visual acuity better than 20/200 was achieved in 30.09% and 24.07% of patients at 3 years and 6 years, respectively, following repeat B-KPro, similar to outcomes observed after the first B-KPro. The incidence of phthisis was higher after the repeat B-KPro, but the rates of hypotony, endophthalmitis, corneal melt, and extrusion were lower compared to the first B-KPro.

Conclusions: Repeat B-KPro can provide sustained visual acuity better than 20/200 after failure of the initial implant. Further studies with larger cohorts are needed to better understand the risks and benefits associated with repeat B-KPro.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信