{"title":"肿瘤精准医疗用半导体芯片人类肿瘤单细胞的鉴定与药物筛选（vol . Sci. 28/2025）","authors":"Wenhao Hui, Ka-Meng Lei, Yingying Liu, Xinru Huang, Yunlong Zhong, Xiaojun Chen, Mingji Wei, Jie Yan, Ren Shen, Pui-In Mak, Rui P. Martins, Shuhong Yi, Ping Wang, Yanwei Jia","doi":"10.1002/advs.202570218","DOIUrl":null,"url":null,"abstract":"<p><b>Impedance Sensing Semiconductor Chip for Precision Medicine</b></p><p>The cover image demonstrates a system integrating single-cell identification and drug screening on a semiconductor chip. In article number 2503131 by Shuhong Yi, Ping Wang, Yanwei Jia, and co-workers, an integrated circuit and microelectrode array is built on a semiconductor chip for single-cell electric cell-substrate impedance sensing (IC-ECIS) of ultra-weak signals, for distinguishing cancer cells from non-cancerous cells obtained from human tumors. Drug screening was run on the same chip after cell identification for dual evaluation of drug efficacy and toxicity in clinical cancer patients.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 28","pages":""},"PeriodicalIF":14.1000,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570218","citationCount":"0","resultStr":"{\"title\":\"Identification and Drug Screening of Single Cells from Human Tumors on Semiconductor Chip for Cancer Precision Medicine (Adv. Sci. 28/2025)\",\"authors\":\"Wenhao Hui, Ka-Meng Lei, Yingying Liu, Xinru Huang, Yunlong Zhong, Xiaojun Chen, Mingji Wei, Jie Yan, Ren Shen, Pui-In Mak, Rui P. Martins, Shuhong Yi, Ping Wang, Yanwei Jia\",\"doi\":\"10.1002/advs.202570218\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Impedance Sensing Semiconductor Chip for Precision Medicine</b></p><p>The cover image demonstrates a system integrating single-cell identification and drug screening on a semiconductor chip. In article number 2503131 by Shuhong Yi, Ping Wang, Yanwei Jia, and co-workers, an integrated circuit and microelectrode array is built on a semiconductor chip for single-cell electric cell-substrate impedance sensing (IC-ECIS) of ultra-weak signals, for distinguishing cancer cells from non-cancerous cells obtained from human tumors. Drug screening was run on the same chip after cell identification for dual evaluation of drug efficacy and toxicity in clinical cancer patients.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure></p>\",\"PeriodicalId\":117,\"journal\":{\"name\":\"Advanced Science\",\"volume\":\"12 28\",\"pages\":\"\"},\"PeriodicalIF\":14.1000,\"publicationDate\":\"2025-07-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570218\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Science\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570218\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570218","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Identification and Drug Screening of Single Cells from Human Tumors on Semiconductor Chip for Cancer Precision Medicine (Adv. Sci. 28/2025)
Impedance Sensing Semiconductor Chip for Precision Medicine
The cover image demonstrates a system integrating single-cell identification and drug screening on a semiconductor chip. In article number 2503131 by Shuhong Yi, Ping Wang, Yanwei Jia, and co-workers, an integrated circuit and microelectrode array is built on a semiconductor chip for single-cell electric cell-substrate impedance sensing (IC-ECIS) of ultra-weak signals, for distinguishing cancer cells from non-cancerous cells obtained from human tumors. Drug screening was run on the same chip after cell identification for dual evaluation of drug efficacy and toxicity in clinical cancer patients.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
