{"title":"无瓣即刻种植体植入与不植骨：系统回顾和荟萃分析","authors":"Saeed Sadat Mansouri, Farhan Musaie, Abbas Mirzaei, Samad Samadizadeh, Salar Chaychi Salmasi, Tahereh Bitaraf","doi":"10.1002/cre2.70182","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study aims to evaluate the influence of bone grafting peri-implant gap on the changes in hard and soft tissues following flapless immediate implantation.</p>\n </section>\n \n <section>\n \n <h3> Material and Methods</h3>\n \n <p>A comprehensive research process was undertaken, including electronic searches of databases such as Embase, PubMed, Web of Science, and Cochrane, as well as a manual search. This approach identified relevant clinical studies until March 2024. Randomized controlled trials (RCTs) that compared flapless immediate implant placement with and without bone grafting were selected for qualitative assessment. Meta-analyses were conducted where feasible. The protocol was registered in PROSPERO with code CRD42024499377, ensuring transparency and accountability in our research.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Out of 1065 articles, 5 RCTs were included, involving 179 patients who underwent placement of 179 immediate implants (92 with bone grafting and 87 without) with follow-up periods ranging from 6 to 12 months. Analysis revealed no significant differences in horizontal bone changes within 0 to 3 mm apical to the bone crest between the two groups (weighted mean difference [WMD]: 0.147 (−0.012, 0.306), <i>I</i><sup>2</sup>: 0.0%; standardized mean difference [SMD]: 0.337 (−0.016, 0.690), <i>I</i><sup>2</sup>: 0.0%). However, significant differences were observed in horizontal bone changes at 4–5 mm apical to the reference point, favoring bone grafting (WMD: 0.484 (0.142, 0.826), <i>I</i><sup>2</sup>: 75.4%; SMD: 0.794 (0.402, 1.186), <i>I</i><sup>2</sup>: 36.6%). No significant differences were found in vertical midfacial soft tissue changes between the groups (WMD: 0.300 (−0.425, 1.024), <i>I</i><sup>2</sup>: 62.4%; SMD: 0.213 (−0.339, 0.764), <i>I</i><sup>2</sup>: 60.2%). Data limitations precluded meta-analyses on additional outcomes such as mesial and distal papillary alterations and vertical bone level changes.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Flapless immediate dental implants with a bone graft may enhance alveolar bone preservation, warranting further investigation.</p>\n </section>\n </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":"11 4","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70182","citationCount":"0","resultStr":"{\"title\":\"Flapless Immediate Implant Placement With and Without Bone Grafting: A Systematic Review and Meta-Analysis\",\"authors\":\"Saeed Sadat Mansouri, Farhan Musaie, Abbas Mirzaei, Samad Samadizadeh, Salar Chaychi Salmasi, Tahereh Bitaraf\",\"doi\":\"10.1002/cre2.70182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>This study aims to evaluate the influence of bone grafting peri-implant gap on the changes in hard and soft tissues following flapless immediate implantation.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Material and Methods</h3>\\n \\n <p>A comprehensive research process was undertaken, including electronic searches of databases such as Embase, PubMed, Web of Science, and Cochrane, as well as a manual search. This approach identified relevant clinical studies until March 2024. Randomized controlled trials (RCTs) that compared flapless immediate implant placement with and without bone grafting were selected for qualitative assessment. Meta-analyses were conducted where feasible. The protocol was registered in PROSPERO with code CRD42024499377, ensuring transparency and accountability in our research.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Out of 1065 articles, 5 RCTs were included, involving 179 patients who underwent placement of 179 immediate implants (92 with bone grafting and 87 without) with follow-up periods ranging from 6 to 12 months. Analysis revealed no significant differences in horizontal bone changes within 0 to 3 mm apical to the bone crest between the two groups (weighted mean difference [WMD]: 0.147 (−0.012, 0.306), <i>I</i><sup>2</sup>: 0.0%; standardized mean difference [SMD]: 0.337 (−0.016, 0.690), <i>I</i><sup>2</sup>: 0.0%). However, significant differences were observed in horizontal bone changes at 4–5 mm apical to the reference point, favoring bone grafting (WMD: 0.484 (0.142, 0.826), <i>I</i><sup>2</sup>: 75.4%; SMD: 0.794 (0.402, 1.186), <i>I</i><sup>2</sup>: 36.6%). No significant differences were found in vertical midfacial soft tissue changes between the groups (WMD: 0.300 (−0.425, 1.024), <i>I</i><sup>2</sup>: 62.4%; SMD: 0.213 (−0.339, 0.764), <i>I</i><sup>2</sup>: 60.2%). Data limitations precluded meta-analyses on additional outcomes such as mesial and distal papillary alterations and vertical bone level changes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Flapless immediate dental implants with a bone graft may enhance alveolar bone preservation, warranting further investigation.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10203,\"journal\":{\"name\":\"Clinical and Experimental Dental Research\",\"volume\":\"11 4\",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.70182\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical and Experimental Dental Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70182\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Dental Research","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cre2.70182","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Flapless Immediate Implant Placement With and Without Bone Grafting: A Systematic Review and Meta-Analysis
Objectives
This study aims to evaluate the influence of bone grafting peri-implant gap on the changes in hard and soft tissues following flapless immediate implantation.
Material and Methods
A comprehensive research process was undertaken, including electronic searches of databases such as Embase, PubMed, Web of Science, and Cochrane, as well as a manual search. This approach identified relevant clinical studies until March 2024. Randomized controlled trials (RCTs) that compared flapless immediate implant placement with and without bone grafting were selected for qualitative assessment. Meta-analyses were conducted where feasible. The protocol was registered in PROSPERO with code CRD42024499377, ensuring transparency and accountability in our research.
Results
Out of 1065 articles, 5 RCTs were included, involving 179 patients who underwent placement of 179 immediate implants (92 with bone grafting and 87 without) with follow-up periods ranging from 6 to 12 months. Analysis revealed no significant differences in horizontal bone changes within 0 to 3 mm apical to the bone crest between the two groups (weighted mean difference [WMD]: 0.147 (−0.012, 0.306), I2: 0.0%; standardized mean difference [SMD]: 0.337 (−0.016, 0.690), I2: 0.0%). However, significant differences were observed in horizontal bone changes at 4–5 mm apical to the reference point, favoring bone grafting (WMD: 0.484 (0.142, 0.826), I2: 75.4%; SMD: 0.794 (0.402, 1.186), I2: 36.6%). No significant differences were found in vertical midfacial soft tissue changes between the groups (WMD: 0.300 (−0.425, 1.024), I2: 62.4%; SMD: 0.213 (−0.339, 0.764), I2: 60.2%). Data limitations precluded meta-analyses on additional outcomes such as mesial and distal papillary alterations and vertical bone level changes.
Conclusion
Flapless immediate dental implants with a bone graft may enhance alveolar bone preservation, warranting further investigation.
期刊介绍：
Clinical and Experimental Dental Research aims to provide open access peer-reviewed publications of high scientific quality representing original clinical, diagnostic or experimental work within all disciplines and fields of oral medicine and dentistry. The scope of Clinical and Experimental Dental Research comprises original research material on the anatomy, physiology and pathology of oro-facial, oro-pharyngeal and maxillofacial tissues, and functions and dysfunctions within the stomatognathic system, and the epidemiology, aetiology, prevention, diagnosis, prognosis and therapy of diseases and conditions that have an effect on the homeostasis of the mouth, jaws, and closely associated structures, as well as the healing and regeneration and the clinical aspects of replacement of hard and soft tissues with biomaterials, and the rehabilitation of stomatognathic functions. Studies that bring new knowledge on how to advance health on the individual or public health levels, including interactions between oral and general health and ill-health are welcome.
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