One pot access to 2-iodo-2-deoxy nucleosides directly from glycals and unprotected nucleobases and their biological evaluation on the Japanese Encephalitis Virus†

An expedient one-pot stereo- and regioselective synthesis of 2-iodo-nucleosides from protected glycals and nucleobases using easily available iodine and hexamethyldisilane as halogenating, and silylating agents respectively has been developed. Most of the products synthesized characterized as diastereomerically pure β-1,2-trans-diequitorial nucleosides hitherto not reported. The in vitro studies unveil the cogent antiviral activity of these newly synthesized nucleoside derivatives against the Japanese Encephalitis Virus (flavivirus) in the Vero cell line.