一种编码60粒尼帕病毒G糖蛋白纳米颗粒的mRNA疫苗引发了针对尼帕病毒的强大中和抗体反应

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-07-22 DOI:10.1016/j.vaccine.2025.127530

Pascal Brandys , César G. Albariño , Shilpi Jain , Irena Merenkova , Nicholas J. Schork , Aihua Deng , Martine Valière , Jens Herold

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引用次数: 0

摘要

尼帕病毒是一种人畜共患病原体，可引起人类脑炎和急性呼吸道疾病，死亡率非常高。在这里，我们报告了一种新的信使RNA疫苗，它直接编码一种纳米颗粒，该纳米颗粒显示尼帕病毒G （NiV G）糖蛋白的60个头部结构域，该糖蛋白作为一种高效抗原。一种编码尼帕病毒G纳米颗粒的疫苗可引起针对尼帕病毒G的高抗体滴度，并与假尼帕病毒系统产生强大的中和抗体反应。我们最终发现，提出的mRNA NiV G纳米颗粒（mRNA NiV G- np）为疫苗的开发提供了一个灵活的平台，这可能在对抗未来尼帕病毒爆发中具有重要价值。

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A mRNA vaccine encoding for a 60-mer Nipah virus G glycoprotein nanoparticle elicits a robust neutralizing antibodies response against the Nipah virus

The Nipah virus is a zoonotic pathogen causing encephalitis and acute respiratory illness in humans with very high fatality rates. Here we report a novel messenger RNA vaccine that directly encodes for a nanoparticle displaying 60 head domains of the Nipah virus G (NiV G) glycoprotein that acts as a highly effective antigen. A vaccine encoding for the NiV G nanoparticle elicits high antibody titers against NiV G and a robust neutralizing antibody response with a pseudotyped Nipah virus system. We ultimately find that the proposed mRNA NiV G nanoparticle (mRNA NiV G-NP) provides a flexible platform for the development of vaccines that will likely be of great value in combatting future Nipah virus outbreaks.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

期刊介绍： Vaccine is unique in publishing the highest quality science across all disciplines relevant to the field of vaccinology - all original article submissions across basic and clinical research, vaccine manufacturing, history, public policy, behavioral science and ethics, social sciences, safety, and many other related areas are welcomed. The submission categories as given in the Guide for Authors indicate where we receive the most papers. Papers outside these major areas are also welcome and authors are encouraged to contact us with specific questions.