基于纳米技术的骨肿瘤治疗

IF 4.9 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

GIANT Pub Date : 2025-07-16 DOI:10.1016/j.giant.2025.100365

Wenwen Zhan , Shuyan Zeng , Lin Yang , Ye-Zhong Zhang , Jing Zhang

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引用次数: 0

摘要

骨肿瘤，特别是骨肉瘤和转移性病变，在目前的诊断和治疗方法中提出了重大挑战，往往不能满足患者对生活质量的期望。近年来，纳米技术的快速发展为骨肿瘤的治疗带来了多样化和更有效的策略。本文综述了纳米医学在骨肿瘤学中的应用，重点讨论了成像方式、图像引导治疗和靶向治疗的新兴发展和未来前景。每个部分都批判性地评估现有诊断和治疗方案的优势和局限性，旨在为骨肿瘤的临床管理提供创新的观点和方法。这些见解的综合旨在弥合目前的技术差距和推进精确医学在肌肉骨骼肿瘤学。

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Nanotechnology-based theranostics for bone tumors

Bone tumors, particularly osteosarcoma and metastatic lesions, present significant challenges in current diagnostic and therapeutic approaches, often failing to meet patients’ expectations for quality of life. Recent rapid advancements in nanotechnology have introduced diverse and more effective strategies for the management of bone tumors. This review comprehensively examines the applications of nanomedicine in bone oncology, with a focused discussion on emerging developments and future prospects in imaging modalities, image-guided therapies, and targeted therapeutics. Each section critically evaluates the strengths and limitations of existing diagnostic and treatment protocols, aiming to provide innovative perspectives and methodologies for clinical management of bone tumors. The synthesis of these insights seeks to bridge current technological gaps and advance precision medicine in musculoskeletal oncology.

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来源期刊

GIANT Multiple-

CiteScore

8.50

自引率

8.60%

发文量

审稿时长

42 days

期刊介绍： Giant is an interdisciplinary title focusing on fundamental and applied macromolecular science spanning all chemistry, physics, biology, and materials aspects of the field in the broadest sense. Key areas covered include macromolecular chemistry, supramolecular assembly, multiscale and multifunctional materials, organic-inorganic hybrid materials, biophysics, biomimetics and surface science. Core topics range from developments in synthesis, characterisation and assembly towards creating uniformly sized precision macromolecules with tailored properties, to the design and assembly of nanostructured materials in multiple dimensions, and further to the study of smart or living designer materials with tuneable multiscale properties.