钯/降冰片烯协同催化五元杂芳烃邻二碳-碳氢功能化研究进展

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-07-23 DOI:10.1016/j.tetlet.2025.155742

Yun Zhou, Renhe Li, Rong Ye, Qi Zhu, Xin Liu, Guangbin Dong

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引用次数: 0

摘要

将两个碳取代基直接引入到功能化程度较低的芳香族核中已经成为复杂分子后期修饰和流线型合成的一个有吸引力的目标。钯/降冰片烯（Pd/NBE）协同催化虽然在双CH功能化方面取得了初步成果，但其反应范围和底物仍有待扩大。本文报道了Pd/ nbe催化的五元杂芳烃通过序贯CH活化的二碳功能化的一些新进展。这些努力包括Pd/ nbe催化的各种呋喃的c4 -芳基化/ c5 -烯基化，噻吩/吡咯的第一个c4 -炔基化，以及初步的c4 -甲基化。2009爱思唯尔有限公司版权所有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Advances in vicinal dicarbo-C–H-functionalization of five-membered heteroarenes via palladium/norbornene cooperative catalysis

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Advances in vicinal dicarbo-C–H-functionalization of five-membered heteroarenes via palladium/norbornene cooperative catalysis

Direct introduction of two carbon substituents to less functionalized aromatic cores has been an attractive objective for late-stage modification and streamlined synthesis of complex molecules. Using the palladium/norbornene (Pd/NBE) cooperative catalysis, while initial achievements on double CH functionalization were made in the past, the scopes of reactions and substrates remain to be expanded. Here we report some new advances on the Pd/NBE-catalyzed dicarbofunctionalization of five-membered heteroarenes through sequential CH activation. These efforts include the Pd/NBE-catalyzed C4-arylation/C5-alkenylation of diverse furans, the first C4-alkynylation of thiophenes/pyrroles, and the preliminary C4-methylation.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.