远端皮质GABA神经元反对酗酒

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-07-23 DOI:10.1038/s41593-025-02030-0

JunShi Wang, Paul J. Kenny

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引用次数: 0

摘要

酗酒现象很普遍，但其潜在的细胞机制尚不清楚。最近的一项研究发现，在狂饮时，内侧眶额皮质中有一个稀疏的gaba能神经元群被激活。这些神经元向皮层下区域发送抑制投射，以限制酒精摄入，这表明了减少酗酒和防止酒精使用障碍的新策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Long-range cortical GABA neurons oppose binge drinking

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Long-range cortical GABA neurons oppose binge drinking

Binge drinking is widespread, but its underlying cellular mechanisms remain unclear. A recent study identifies a sparse ensemble of GABAergic neurons in the medial orbitofrontal cortex that is activated during binge drinking. These neurons send inhibitory projections to subcortical regions to limit alcohol intake, suggesting new strategies to reduce binge drinking and protect against alcohol use disorder.

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.