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双（乙氧基）碘苯介导的Grob-Ugi级联反应在醋酸盐多功能利用中的应用

IF 3.6 2区 化学 Q1 CHEMISTRY, ORGANIC
Journal of Organic Chemistry Pub Date : 2025-07-22 DOI:10.1021/acs.joc.5c01254
Jing Li*, Kun Yin, Ziyue Ma, Haoran Chu and Hongwei Kang*, 
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引用次数: 0

摘要

利用醋酸盐在高价碘试剂中的多官能性，实现了Grob-Ugi级联反应。优化了三氟乙醇与双（乙酰氧基）碘苯、氨基甲酸铵和异氰酸酯的反应条件，得到了2-氨基酰胺衍生物。初步研究表明，这一过程分为三步：碘（III）中间体的形成、醋酸盐介导的grob型断裂和醋酸盐诱导的Ugi组装。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bis(acetoxy)iodobenzene-Mediated Grob-Ugi Cascade Reaction Enabled by Multifunctional Utilization of Acetate

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Bis(acetoxy)iodobenzene-Mediated Grob-Ugi Cascade Reaction Enabled by Multifunctional Utilization of Acetate

The Grob-Ugi cascade reaction was achieved by utilizing the multifunctionality of acetate in hypervalent iodine reagents. Optimized conditions in trifluoroethanol with bis(acetoxy)iodobenzene, ammonium carbamate, and isocyanides afforded 2-carbamimidamide derivatives. Preliminary studies suggest a three-step sequence: formation of an iodine(III) intermediate, acetate-mediated Grob-type fragmentation, and iminium-acetate-induced Ugi assembly.

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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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