用小分子光敏剂和光诱导NO供体构建ONOO-发生器用于肿瘤治疗。

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Mengqi Liu, Yuqing Liu, Shaoqi Xie, Jiachen Xia, Tong Sun and Bing Lu
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引用次数: 0

摘要

多模式协同治疗是提高肿瘤治疗效果的有效手段。本文构建了一个通过生成过氧亚硝酸盐(ONOO-)进行高效光动力和NO协同治疗的纳米治疗平台。具体来说,设计了一种新型的小分子光敏剂(DMATPE-MN)和光诱导NO供体(NTA-CN),它们在可见光区具有相似的光吸收。在相同的光照射下,DMATPE-MN和NTA-CN分别产生超氧阴离子自由基(O2˙-)和NO自由基。然后,将NTA-CN和DMATPE-MN通过主-客体和亲/疏水机制整合成两亲性柱芳烃(WP5-PEG-OH)的纳米载体。令人振奋的是,与WP5-PEG-OH进行主客体络合后,NTA-CN的NO生成效率显著提高。更令人兴奋的是,所形成的纳米药物WP5-NTA/MN在光照射下可以生成ONOO-。结果表明,WP5-NTA/MN在常氧和缺氧条件下均表现出良好的生物相容性和较高的肿瘤细胞致死率。此外,体内实验结果也表明其具有良好的生物安全性和抑制肿瘤生长的能力。因此,我们为多模式协同治疗提供了一个非常有前途的纳米平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

ONOO− generator constructed with a small molecule photosensitizer and photoinduced NO donor for tumor therapy†

ONOO− generator constructed with a small molecule photosensitizer and photoinduced NO donor for tumor therapy†

Multimodal synergistic therapy is an effective means to improve therapeutic outcomes against cancer. Herein, a nanotherapeutic platform for highly efficient photodynamic and NO synergistic therapy through the generation of peroxynitrite (ONOO) was constructed. Specifically, a new small molecule photosensitizer (DMATPE-MN) and photoinduced NO donor (NTA-CN) were subtly designed, which displayed similar light absorption in the visible light region. Under the same light irradiation, DMATPE-MN and NTA-CN can generate a superoxide anion free radical (O2˙) and an NO radical, respectively. Then, NTA-CN and DMATPE-MN were integrated together into nanocarriers formed from amphiphilic pillararene (WP5-PEG-OH) through host–guest and hydrophilic/hydrophobic mechanisms. Exhilaratingly, the NO generation efficiency of NTA-CN can be significantly improved after host–guest complexation with WP5-PEG-OH. It is even more exciting that the formed nanodrug WP5-NTA/MN can generate ONOO after light irradiation. As a result, WP5-NTA/MN exhibited outstanding biocompability and showed high tumor cell lethality under both normoxic and hypoxic conditions. Furthermore, the experimental results in vivo also demonstrated its good biosafety and ability to inhibit tumor growth. Thus, we provided a highly promising nanoplatform for multimodal synergistic therapy.

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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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