Mengqi Liu, Yuqing Liu, Shaoqi Xie, Jiachen Xia, Tong Sun and Bing Lu
{"title":"用小分子光敏剂和光诱导NO供体构建ONOO-发生器用于肿瘤治疗。","authors":"Mengqi Liu, Yuqing Liu, Shaoqi Xie, Jiachen Xia, Tong Sun and Bing Lu","doi":"10.1039/D5TB00937E","DOIUrl":null,"url":null,"abstract":"<p >Multimodal synergistic therapy is an effective means to improve therapeutic outcomes against cancer. Herein, a nanotherapeutic platform for highly efficient photodynamic and NO synergistic therapy through the generation of peroxynitrite (ONOO<small><sup>−</sup></small>) was constructed. Specifically, a new small molecule photosensitizer (<strong>DMATPE-MN</strong>) and photoinduced NO donor (<strong>NTA-CN</strong>) were subtly designed, which displayed similar light absorption in the visible light region. Under the same light irradiation, <strong>DMATPE-MN</strong> and <strong>NTA-CN</strong> can generate a superoxide anion free radical (O<small><sub>2</sub></small>˙<small><sup>−</sup></small>) and an NO radical, respectively. Then, <strong>NTA-CN</strong> and <strong>DMATPE-MN</strong> were integrated together into nanocarriers formed from amphiphilic pillararene (<strong>WP5-PEG-OH</strong>) through host–guest and hydrophilic/hydrophobic mechanisms. Exhilaratingly, the NO generation efficiency of <strong>NTA-CN</strong> can be significantly improved after host–guest complexation with <strong>WP5-PEG-OH</strong>. It is even more exciting that the formed nanodrug WP5-NTA/MN can generate ONOO<small><sup>−</sup></small> after light irradiation. As a result, WP5-NTA/MN exhibited outstanding biocompability and showed high tumor cell lethality under both normoxic and hypoxic conditions. Furthermore, the experimental results <em>in vivo</em> also demonstrated its good biosafety and ability to inhibit tumor growth. Thus, we provided a highly promising nanoplatform for multimodal synergistic therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 32","pages":" 9876-9882"},"PeriodicalIF":6.1000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ONOO− generator constructed with a small molecule photosensitizer and photoinduced NO donor for tumor therapy†\",\"authors\":\"Mengqi Liu, Yuqing Liu, Shaoqi Xie, Jiachen Xia, Tong Sun and Bing Lu\",\"doi\":\"10.1039/D5TB00937E\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Multimodal synergistic therapy is an effective means to improve therapeutic outcomes against cancer. Herein, a nanotherapeutic platform for highly efficient photodynamic and NO synergistic therapy through the generation of peroxynitrite (ONOO<small><sup>−</sup></small>) was constructed. Specifically, a new small molecule photosensitizer (<strong>DMATPE-MN</strong>) and photoinduced NO donor (<strong>NTA-CN</strong>) were subtly designed, which displayed similar light absorption in the visible light region. Under the same light irradiation, <strong>DMATPE-MN</strong> and <strong>NTA-CN</strong> can generate a superoxide anion free radical (O<small><sub>2</sub></small>˙<small><sup>−</sup></small>) and an NO radical, respectively. Then, <strong>NTA-CN</strong> and <strong>DMATPE-MN</strong> were integrated together into nanocarriers formed from amphiphilic pillararene (<strong>WP5-PEG-OH</strong>) through host–guest and hydrophilic/hydrophobic mechanisms. Exhilaratingly, the NO generation efficiency of <strong>NTA-CN</strong> can be significantly improved after host–guest complexation with <strong>WP5-PEG-OH</strong>. It is even more exciting that the formed nanodrug WP5-NTA/MN can generate ONOO<small><sup>−</sup></small> after light irradiation. As a result, WP5-NTA/MN exhibited outstanding biocompability and showed high tumor cell lethality under both normoxic and hypoxic conditions. Furthermore, the experimental results <em>in vivo</em> also demonstrated its good biosafety and ability to inhibit tumor growth. Thus, we provided a highly promising nanoplatform for multimodal synergistic therapy.</p>\",\"PeriodicalId\":83,\"journal\":{\"name\":\"Journal of Materials Chemistry B\",\"volume\":\" 32\",\"pages\":\" 9876-9882\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Materials Chemistry B\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb00937e\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Chemistry B","FirstCategoryId":"1","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/tb/d5tb00937e","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
ONOO− generator constructed with a small molecule photosensitizer and photoinduced NO donor for tumor therapy†
Multimodal synergistic therapy is an effective means to improve therapeutic outcomes against cancer. Herein, a nanotherapeutic platform for highly efficient photodynamic and NO synergistic therapy through the generation of peroxynitrite (ONOO−) was constructed. Specifically, a new small molecule photosensitizer (DMATPE-MN) and photoinduced NO donor (NTA-CN) were subtly designed, which displayed similar light absorption in the visible light region. Under the same light irradiation, DMATPE-MN and NTA-CN can generate a superoxide anion free radical (O2˙−) and an NO radical, respectively. Then, NTA-CN and DMATPE-MN were integrated together into nanocarriers formed from amphiphilic pillararene (WP5-PEG-OH) through host–guest and hydrophilic/hydrophobic mechanisms. Exhilaratingly, the NO generation efficiency of NTA-CN can be significantly improved after host–guest complexation with WP5-PEG-OH. It is even more exciting that the formed nanodrug WP5-NTA/MN can generate ONOO− after light irradiation. As a result, WP5-NTA/MN exhibited outstanding biocompability and showed high tumor cell lethality under both normoxic and hypoxic conditions. Furthermore, the experimental results in vivo also demonstrated its good biosafety and ability to inhibit tumor growth. Thus, we provided a highly promising nanoplatform for multimodal synergistic therapy.
期刊介绍:
Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive:
Antifouling coatings
Biocompatible materials
Bioelectronics
Bioimaging
Biomimetics
Biomineralisation
Bionics
Biosensors
Diagnostics
Drug delivery
Gene delivery
Immunobiology
Nanomedicine
Regenerative medicine & Tissue engineering
Scaffolds
Soft robotics
Stem cells
Therapeutic devices