通过ATAT1的B细胞机械转导协调免疫突触的肌动蛋白和溶酶体动力学。

IF 6.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-08-04 Epub Date: 2025-07-21 DOI:10.1083/jcb.202506017

Srishti Mandal, Sudha Kumari

引用次数: 0

摘要

在本期中，（Aceitón等人https://doi.org/10.1083/jcb.202407181）揭示了将B细胞免疫突触的刚性感应与ATAT1的分子转运联系在一起的途径，导致微管乙酰化和溶酶体重新定位，最终调整B细胞对抗原摄取和递呈的效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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B cell mechanotransduction via ATAT1 coordinates actin and lysosomal dynamics at the immune synapse.

In this issue, (Aceitón et al. https://doi.org/10.1083/jcb.202407181) uncover a pathway that ties together rigidity sensing at the B cell immunological synapse to molecular shuttling of ATAT1, leading to microtubule acetylation and lysosome repositioning, ultimately tuning the efficiency of antigen uptake and presentation by B cells.

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.