用微生理系统方法设计胃肠系统。

IF 3.6 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Vidhi Mathur, Mrunmayi Gadre, Amrutha H K, Kirthanashri S Vasanthan
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引用次数: 0

摘要

胃肠道(GI)系统是一个复杂的动态器官系统,其解剖结构和各种生理功能增加了营养吸收、免疫功能和整体健康维护的复杂性。这篇综述从解剖学的概述开始,重点介绍了关键器官及其各自的作用,然后探索了功能和生理学,详细介绍了消化机制和微生物相互作用。传统的体外模型和动物研究往往不能准确地复制人类肠道的复杂环境。微生理系统(MPS)提供了创新的解决方案,集成了3D生物打印、球体、类器官和微流体等先进技术,以创建更准确和动态的模型,并已成为弥合这一差距的有希望的解决方案。本文深入研究了MPS在胃肠道系统中的应用,包括提供结构保真度的3D生物打印模型,模拟细胞复杂性的肠道类器官,以及重建生理环境的肠道芯片设备。MPS在克服传统模型的局限性和加速GI领域的生物医学研究和治疗开发方面的变革潜力正在得到很好的研究。这些尖端技术有望增强我们对胃肠道生物学的理解,改善药物测试,推进个性化医疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A microphysiological systems approach to design gastrointestinal system.

The gastrointestinal (GI) system is a complex and dynamic organ system, with the anatomy and varied physiological functionality adding complexity to nutrient absorption, immune function, and maintenance of overall health. This review begins with an overview of the anatomy, highlighting key organs and their respective roles, followed by an exploration of the functionality and physiology, detailing mechanisms of digestion, and microbial interactions. Traditional in vitro models and animal studies often fall short in accurately replicating the intricate environment of the human gut. Microphysiological systems (MPS) offer innovative solutions, integrating advanced techniques such as 3D bioprinting, spheroids, organoids, and microfluidics to create more accurate and dynamic models and have emerged as promising solutions to bridge this gap. This paper delves into the applications of MPS in the context of the GI system, including 3D bioprinted models that provide structural fidelity, intestinal organoids that mimic cellular complexity, and gut-on-chip devices that recreate the physiological environment. The transformative potential of MPS in overcoming the limitations of conventional models and accelerating biomedical research and therapeutic development in the GI domain is being well studied. These cutting-edge technologies hold promise for enhancing our understanding of GI biology, improving drug testing, and advancing personalized medicine.

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来源期刊
Journal of Biomaterials Science, Polymer Edition
Journal of Biomaterials Science, Polymer Edition 工程技术-材料科学:生物材料
CiteScore
7.10
自引率
5.60%
发文量
117
审稿时长
1.5 months
期刊介绍: The Journal of Biomaterials Science, Polymer Edition publishes fundamental research on the properties of polymeric biomaterials and the mechanisms of interaction between such biomaterials and living organisms, with special emphasis on the molecular and cellular levels. The scope of the journal includes polymers for drug delivery, tissue engineering, large molecules in living organisms like DNA, proteins and more. As such, the Journal of Biomaterials Science, Polymer Edition combines biomaterials applications in biomedical, pharmaceutical and biological fields.
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