接受放射治疗的儿童脑肿瘤幸存者脑亚结构剂量与学习成绩的关系。

IF 6.5 1区 医学 Q1 ONCOLOGY
Raymond B Mailhot Vega, Daniel J Indelicato, Julie A Bradley, Erin M Mobley, Emma Viviers, Christopher G Morris, Adeel Markatia, Yousef Ramahi, Christine F Delgado, Carla L Fisher, Nancy P Mendenhall, Kimberly P Raghubar, Amy M Crisp, M David Miller
{"title":"接受放射治疗的儿童脑肿瘤幸存者脑亚结构剂量与学习成绩的关系。","authors":"Raymond B Mailhot Vega, Daniel J Indelicato, Julie A Bradley, Erin M Mobley, Emma Viviers, Christopher G Morris, Adeel Markatia, Yousef Ramahi, Christine F Delgado, Carla L Fisher, Nancy P Mendenhall, Kimberly P Raghubar, Amy M Crisp, M David Miller","doi":"10.1016/j.ijrobp.2025.07.1418","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Radiotherapy may cause cognitive deficits in pediatric brain tumor survivors (PBTS). Scholastic data provides pre-diagnostic measurements, is practical for patients and families, and aligns with student learning before and after treatment. We evaluated the association between radiation dose to organs at risk (OARs) and scholastic achievement in PBTS.</p><p><strong>Materials/methods: </strong>With IRB approval, we retrospectively analyzed scholastic achievement in PBTS treated with radiation from 2007-2021 at our institution. The state's Department of Education (DOE) provided scholastic data, merged with institutional clinical data. DOE also provided scholastic data on healthy children matched 3:1. A general linear mixed-effects model was performed with scholastic dependent variables from the post-treatment phase and the independent variable of mean OAR dose to the hippocampus, corpus callosum (CC), and frontal lobe (FL). Sensitivity analysis was conducted, limited to only children in the treatment group. Exploratory analyses evaluating volumetric associations between OARs and scholastic outcomes were conducted.</p><p><strong>Results: </strong>Fifty PBTS and 150 matched controls were included with a median age of 11.6 years at treatment and 7 years of follow-up. In the primary model, increasing mean dose to the hippocampus (p = 0.048), CC (p = 0.053), and FL (p = 0.097) were negatively associated with standard grade promotion. In the secondary model restricted to PBTS, only hippocampal dose remained significantly associated with grade promotion (p = 0.092). Volumetric analyses determined negative associations between higher V5-V20 to the hippocampus and FL and Mathematics and higher V25-V40 to the FL and Reading.</p><p><strong>Conclusions: </strong>We present the first ever report evaluating associations between dosimetry and scholastic performance. We demonstrate a novel method using scholastic performance data as a patient-centered metric, leveraging prospectively state-collected scholastic outcomes.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.5000,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between brain substructure dose and scholastic performance in pediatric brain tumor survivors who received radiotherapy.\",\"authors\":\"Raymond B Mailhot Vega, Daniel J Indelicato, Julie A Bradley, Erin M Mobley, Emma Viviers, Christopher G Morris, Adeel Markatia, Yousef Ramahi, Christine F Delgado, Carla L Fisher, Nancy P Mendenhall, Kimberly P Raghubar, Amy M Crisp, M David Miller\",\"doi\":\"10.1016/j.ijrobp.2025.07.1418\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Radiotherapy may cause cognitive deficits in pediatric brain tumor survivors (PBTS). Scholastic data provides pre-diagnostic measurements, is practical for patients and families, and aligns with student learning before and after treatment. We evaluated the association between radiation dose to organs at risk (OARs) and scholastic achievement in PBTS.</p><p><strong>Materials/methods: </strong>With IRB approval, we retrospectively analyzed scholastic achievement in PBTS treated with radiation from 2007-2021 at our institution. The state's Department of Education (DOE) provided scholastic data, merged with institutional clinical data. DOE also provided scholastic data on healthy children matched 3:1. A general linear mixed-effects model was performed with scholastic dependent variables from the post-treatment phase and the independent variable of mean OAR dose to the hippocampus, corpus callosum (CC), and frontal lobe (FL). Sensitivity analysis was conducted, limited to only children in the treatment group. Exploratory analyses evaluating volumetric associations between OARs and scholastic outcomes were conducted.</p><p><strong>Results: </strong>Fifty PBTS and 150 matched controls were included with a median age of 11.6 years at treatment and 7 years of follow-up. In the primary model, increasing mean dose to the hippocampus (p = 0.048), CC (p = 0.053), and FL (p = 0.097) were negatively associated with standard grade promotion. In the secondary model restricted to PBTS, only hippocampal dose remained significantly associated with grade promotion (p = 0.092). Volumetric analyses determined negative associations between higher V5-V20 to the hippocampus and FL and Mathematics and higher V25-V40 to the FL and Reading.</p><p><strong>Conclusions: </strong>We present the first ever report evaluating associations between dosimetry and scholastic performance. We demonstrate a novel method using scholastic performance data as a patient-centered metric, leveraging prospectively state-collected scholastic outcomes.</p>\",\"PeriodicalId\":14215,\"journal\":{\"name\":\"International Journal of Radiation Oncology Biology Physics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2025-07-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Oncology Biology Physics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ijrobp.2025.07.1418\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Oncology Biology Physics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijrobp.2025.07.1418","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:放疗可能导致儿童脑肿瘤幸存者(PBTS)的认知缺陷。学术数据提供了诊断前的测量,对患者和家庭是实用的,并与治疗前后的学生学习一致。我们评估了危险器官辐射剂量(OARs)与PBTS学业成绩之间的关系。材料/方法:经IRB批准,我们回顾性分析了我院2007-2021年放疗PBTS的学术成果。该州教育部(DOE)提供了学术数据,并合并了机构临床数据。美国能源部还提供了健康儿童的学术数据,比例为3:1。采用治疗后阶段的学术因变量和海马、胼胝体(CC)和额叶(FL)的平均OAR剂量自变量建立一般线性混合效应模型。对治疗组仅限儿童进行敏感性分析。进行了探索性分析,评估桨叶容积与学业成绩之间的关联。结果:纳入50例PBTS和150例匹配对照,治疗时的中位年龄为11.6岁,随访7年。在初级模型中,海马平均剂量的增加(p = 0.048)、CC (p = 0.053)和FL (p = 0.097)与标准等级的提升呈负相关。在局限于PBTS的二级模型中,只有海马剂量与分级提升保持显著相关(p = 0.092)。容量分析表明,海马区V5-V20的升高与FL和数学呈正相关,V25-V40的升高与FL和阅读呈正相关。结论:我们提出了第一份评估剂量学与学习成绩之间关系的报告。我们展示了一种新的方法,使用学习成绩数据作为以患者为中心的指标,利用前瞻性的国家收集的学术成果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between brain substructure dose and scholastic performance in pediatric brain tumor survivors who received radiotherapy.

Purpose: Radiotherapy may cause cognitive deficits in pediatric brain tumor survivors (PBTS). Scholastic data provides pre-diagnostic measurements, is practical for patients and families, and aligns with student learning before and after treatment. We evaluated the association between radiation dose to organs at risk (OARs) and scholastic achievement in PBTS.

Materials/methods: With IRB approval, we retrospectively analyzed scholastic achievement in PBTS treated with radiation from 2007-2021 at our institution. The state's Department of Education (DOE) provided scholastic data, merged with institutional clinical data. DOE also provided scholastic data on healthy children matched 3:1. A general linear mixed-effects model was performed with scholastic dependent variables from the post-treatment phase and the independent variable of mean OAR dose to the hippocampus, corpus callosum (CC), and frontal lobe (FL). Sensitivity analysis was conducted, limited to only children in the treatment group. Exploratory analyses evaluating volumetric associations between OARs and scholastic outcomes were conducted.

Results: Fifty PBTS and 150 matched controls were included with a median age of 11.6 years at treatment and 7 years of follow-up. In the primary model, increasing mean dose to the hippocampus (p = 0.048), CC (p = 0.053), and FL (p = 0.097) were negatively associated with standard grade promotion. In the secondary model restricted to PBTS, only hippocampal dose remained significantly associated with grade promotion (p = 0.092). Volumetric analyses determined negative associations between higher V5-V20 to the hippocampus and FL and Mathematics and higher V25-V40 to the FL and Reading.

Conclusions: We present the first ever report evaluating associations between dosimetry and scholastic performance. We demonstrate a novel method using scholastic performance data as a patient-centered metric, leveraging prospectively state-collected scholastic outcomes.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
11.00
自引率
7.10%
发文量
2538
审稿时长
6.6 weeks
期刊介绍: International Journal of Radiation Oncology • Biology • Physics (IJROBP), known in the field as the Red Journal, publishes original laboratory and clinical investigations related to radiation oncology, radiation biology, medical physics, and both education and health policy as it relates to the field. This journal has a particular interest in original contributions of the following types: prospective clinical trials, outcomes research, and large database interrogation. In addition, it seeks reports of high-impact innovations in single or combined modality treatment, tumor sensitization, normal tissue protection (including both precision avoidance and pharmacologic means), brachytherapy, particle irradiation, and cancer imaging. Technical advances related to dosimetry and conformal radiation treatment planning are of interest, as are basic science studies investigating tumor physiology and the molecular biology underlying cancer and normal tissue radiation response.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信