革命性的癌症治疗:工程间充质干细胞衍生的小细胞外囊泡。

IF 6 2区 医学 Q1 ONCOLOGY
Ameneh Shokati, Mahshid Akhavan Rahnama, Ladan Jalali, Saghar Hoseinzadeh, Saman Masoudifar, Mohammad Ahmadvand
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引用次数: 0

摘要

近年来,利用外泌体是治疗癌症的重要途径之一。间充质干细胞是一种多能干细胞,被认为是调节免疫系统和抑制肿瘤细胞免疫反应的重要来源。从间充质干细胞中提取的小细胞外囊泡(Small extracellular vesicles,简称EVs)可以通过调节信号通路向癌细胞和肿瘤输送靶向药物。外泌体在癌症治疗中的应用存在挑战,需要改进。小型电动汽车的工程设计可以恢复外泌体的作用,如药物输送和治疗工具。从小型ev中提取的间充质干细胞的临床前和临床研究证明了这些方法在癌症领域的有效性。考虑到大规模生产等方面的问题,工程化小型电动汽车作为癌症治疗方法的结果是,它们保留了来自细胞的大部分特征,这些特征负责其免疫调节作用,驱动肿瘤微环境的积极变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles.

Revolutionizing cancer treatment: engineering mesenchymal stem cell-derived small extracellular vesicles.

In recent years, use of exosomes is one of the important approaches to treat cancer. Mesenchymal stem cells are multipotent stem cells which are very putative sources for modulating the immune system and importantly inhibiting immune responses against tumor cells. Small extracellular vesicles (small EVs) are extracted from mesenchymal stem cells can have therapeutic approaches for delivering targeted drugs to cancer cells and also tumors via regulation of signaling pathways.There are challenges in use of exosomes in cancer treatment which need to be improved. Engineering in small EVs can recover the role of exosomes such as drug delivery and therapeutic tools. There are preclinical and clinical studies in the field of mesenchymal stem cells derived from small EVs which demonstrates efficacy of these approaches in the field of cancer.In consideration of problems in large scale production and so on, engineered small EVs as treatment approaches for cancers, it is resulted that they retain most characteristics of cells which are derived from, are responsible for their immunomodulatory impacts driving positive changes in the tumor microenvironment.

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来源期刊
CiteScore
10.90
自引率
1.70%
发文量
360
审稿时长
1 months
期刊介绍: Cancer Cell International publishes articles on all aspects of cancer cell biology, originating largely from, but not limited to, work using cell culture techniques. The journal focuses on novel cancer studies reporting data from biological experiments performed on cells grown in vitro, in two- or three-dimensional systems, and/or in vivo (animal experiments). These types of experiments have provided crucial data in many fields, from cell proliferation and transformation, to epithelial-mesenchymal interaction, to apoptosis, and host immune response to tumors. Cancer Cell International also considers articles that focus on novel technologies or novel pathways in molecular analysis and on epidemiological studies that may affect patient care, as well as articles reporting translational cancer research studies where in vitro discoveries are bridged to the clinic. As such, the journal is interested in laboratory and animal studies reporting on novel biomarkers of tumor progression and response to therapy and on their applicability to human cancers.
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