{"title":"分子标记的发现和评价：中国肺腺癌年轻人群中EGF rs1897990和rs1524106变异","authors":"Huiwen Pan, Xiangyang Wang, Lijie Zheng, Jinye Wang, Guowen Ding, Jingfeng Zhu, Zhijie Fang","doi":"10.1111/crj.70113","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>The objective of this study is to investigate the genetic susceptibility and risk factors of <i>EGF</i> gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A case–control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single-nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of <i>EGF</i> gene rs1897990 CT heterozygous mutant was different between the two groups (<i>p</i> = 0.021). The T alleles of <i>EGF</i> rs1897990 and rs1524106 were significantly different between the two groups (<i>p</i> = 0.034 and <i>p</i> = 0.023).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>The young lung adenocarcinoma population (≤ 45 years old) is susceptible to <i>EGF</i> rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of <i>EGF</i> rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma.</p>\n </section>\n </div>","PeriodicalId":55247,"journal":{"name":"Clinical Respiratory Journal","volume":"19 7","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70113","citationCount":"0","resultStr":"{\"title\":\"Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population\",\"authors\":\"Huiwen Pan, Xiangyang Wang, Lijie Zheng, Jinye Wang, Guowen Ding, Jingfeng Zhu, Zhijie Fang\",\"doi\":\"10.1111/crj.70113\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>The objective of this study is to investigate the genetic susceptibility and risk factors of <i>EGF</i> gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>A case–control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single-nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of <i>EGF</i> gene rs1897990 CT heterozygous mutant was different between the two groups (<i>p</i> = 0.021). The T alleles of <i>EGF</i> rs1897990 and rs1524106 were significantly different between the two groups (<i>p</i> = 0.034 and <i>p</i> = 0.023).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>The young lung adenocarcinoma population (≤ 45 years old) is susceptible to <i>EGF</i> rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of <i>EGF</i> rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma.</p>\\n </section>\\n </div>\",\"PeriodicalId\":55247,\"journal\":{\"name\":\"Clinical Respiratory Journal\",\"volume\":\"19 7\",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2025-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/crj.70113\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Respiratory Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/crj.70113\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Respiratory Journal","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/crj.70113","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
Molecular Marker Discovery and Evaluation: EGF rs1897990 and rs1524106 Variants in a China Lung Adenocarcinoma Young Population
Objective
The objective of this study is to investigate the genetic susceptibility and risk factors of EGF gene rs1897990 and rs1524106 in lung adenocarcinoma young patients aged ≤ 45 years.
Methods
A case–control study was conducted. DNA was extracted and identified from 88 samples from case and control groups by single-nucleotide polymorphism assay. PCR amplification was performed by TaqMan probe method, and the factors of smoking, drinking, sex, and age were also included. To investigate the clinical factors and genotyping differences between case and control groups.
Results
Smoking was an influential factor in young lung adenocarcinoma patients. The mutation frequency of EGF gene rs1897990 CT heterozygous mutant was different between the two groups (p = 0.021). The T alleles of EGF rs1897990 and rs1524106 were significantly different between the two groups (p = 0.034 and p = 0.023).
Conclusions
The young lung adenocarcinoma population (≤ 45 years old) is susceptible to EGF rs1897990 and rs1524106 variants, with smoking being another risk factor. Additionally, smoking may enhance the risk of EGF rs1897990 and rs1524106 variants threatening the development of lung adenocarcinoma.
期刊介绍：
Overview
Effective with the 2016 volume, this journal will be published in an online-only format.
Aims and Scope
The Clinical Respiratory Journal (CRJ) provides a forum for clinical research in all areas of respiratory medicine from clinical lung disease to basic research relevant to the clinic.
We publish original research, review articles, case studies, editorials and book reviews in all areas of clinical lung disease including:
Asthma
Allergy
COPD
Non-invasive ventilation
Sleep related breathing disorders
Interstitial lung diseases
Lung cancer
Clinical genetics
Rhinitis
Airway and lung infection
Epidemiology
Pediatrics
CRJ provides a fast-track service for selected Phase II and Phase III trial studies.
Keywords
Clinical Respiratory Journal, respiratory, pulmonary, medicine, clinical, lung disease,
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HEED: Health Economic Evaluations Database (Wiley-Blackwell)
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Journal Citation Reports/Science Edition (Clarivate Analytics)
MEDLINE/PubMed (NLM)
ProQuest Central (ProQuest)
Science Citation Index Expanded (Clarivate Analytics)
SCOPUS (Elsevier)
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