化学光遗传二聚化分解复杂的生物过程（Small Methods 7/2025）

IF 9.1 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Small Methods Pub Date : 2025-07-23 DOI:10.1002/smtd.202570042

Donglian Wu, Xiaofeng Sun, Xi Chen

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引用次数: 0

摘要

近年来，以光响应二聚化化学诱导剂（pCIDs）为代表的化学光遗传学二聚化工具被开发出来用于细胞功能的时空调控。这些二聚体能够开启（paCID）、关闭（pdCID）或在细胞活动的开/关（psCID）之间切换。除了小分子pCIDs外，纳米体共轭光二聚体也在不断涌现。这些进步为解剖复杂的生物过程创造了新的机会。在文章编号2401271，陈和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemo-optogenetic Dimerization Dissects Complex Biological Processes (Small Methods 7/2025)

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Chemo-optogenetic Dimerization Dissects Complex Biological Processes (Small Methods 7/2025)

Inside Front Cover

In recent years, chemo-optogenetic dimerization tools, represented by photo-responsive chemical inducers of dimerization (pCIDs), have been developed for spatiotemporal regulation of cellular functions. These dimerizers enable turning ON (paCID), turning OFF (pdCID), or switching between ON/OFF (psCID) of cellular activities. Apart from small molecule pCIDs, nanobody-conjugate photodimerizers are also emerging. These advancements create new opportunities for dissecting complex biological processes. More in article number 2401271, Chen and co-workers.

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来源期刊

Small Methods Materials Science-General Materials Science

CiteScore

17.40

自引率

1.60%

发文量

347

期刊介绍： Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.